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Mouse Anti-CNDP2 Recombinant Antibody (1A6) (CBMAB-C3572-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A6
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
CNDP2 (191 a.a. ~ 300 a.a) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carnosine Dipeptidase 2
Introduction
CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
55748
UniProt ID
Q96KP4
Alternative Names
Carnosine Dipeptidase 2; Carnosine Dipeptidase II; Peptidase A; CNDP Dipeptidase 2 (Metallopeptidase M20 Family); Glutamate Carboxypeptidase-Like Protein 1; Epididymis Secretory Protein Li 13; Cytosolic Nonspecific Dipeptidase; Carnosinase-2; HEL-S-13;
Function
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245).

Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568).

Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880).

Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).
Biological Process
Glutathione biosynthetic process Source: Reactome
Proteolysis Source: GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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