Mouse Anti-CNDP2 Recombinant Antibody (CBFYC-0296) (V2LY-1206-LY414)

Name: Mouse Anti-CNDP2 Recombinant Antibody (CBFYC-0296)
SKU: V2LY-1206-LY414
Rating: 5 (1 reviews)

See all CNDP2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-0296

Application

WB, IP, IF, ELISA, FC

Immunogen

Amino acids 1-475 of CNDP2 of human.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

<0.1% sodium azide

Concentration

0.1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Carnosine Dipeptidase 2

Entrez Gene ID

Human	55748
Mouse	66054

UniProt ID

Human	Q96KP4
Mouse	Q9D1A2

Function

Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245).

Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568).

Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880).

Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).

Biological Process

Glutathione biosynthetic process Source: Reactome
Proteolysis Source: GO_Central

Cellular Location

Cytoplasm

Kobayashi, S., Homma, T., Okumura, N., Han, J., Nagaoka, K., Sato, H., ... & Fujii, J. (2021). Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides. Free Radical Biology and Medicine, 174, 12-27.

Andreyeva, E. N., Ogienko, A. A., Dubatolova, T. D., Oshchepkova, A. L., Kozhevnikova, E. N., Ivankin, A. V., ... & Pindyurin, A. V. (2019). A toolset to study functions of Cytosolic non-specific dipeptidase 2 (CNDP2) using Drosophila as a model organism. BMC genetics, 20(1), 15-23.

Zhang, L. Q., Yang, H. Q., Yang, S. Q., Wang, Y., Chen, X. J., Lu, H. S., & Zhao, L. P. (2019). CNDP2 acts as an activator for human ovarian cancer growth and metastasis via the PI3K/AKT pathway. Technology in Cancer Research & Treatment, 18, 1533033819874773.

Asgarbeik, S., Razi, F., Nasli-Esfahani, E., Enayati, S., Angaji, S., Mashkani, M. A., ... & Amoli, M. M. (2019). Investigating the association of rs2346061 (CNDP1), rs7577 (CNDP2), and rs1801133 (MTHFR) variants and homocysteine level with diabetic nephropathy in an Iranian population. Gene Reports, 16, 100443.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-CNDP2 Recombinant Antibody (CBFYC-0296)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

CNDP2 Matched Antibody Pair (279) (CAT#: APMAB-279LY)

CNDP2 Matched Antibody Pair (280) (CAT#: APMAB-280LY)

CNDP2 Matched Antibody Pair (281) (CAT#: APMAB-281LY)

Related Products

CNDP2 Matched Antibody Pair (281) (CAT#: APMAB-281LY)

Mouse Anti-CNDP2 Recombinant Antibody (1B1) (CAT#: V2LY-1206-LY415)

Mouse Anti-CNDP2 Recombinant Antibody (C1327) (CAT#: V2LY-1206-LY410)

Mouse Anti-CNDP2 Recombinant Antibody (1A6) (CAT#: CBMAB-C3572-LY)

Mouse Anti-CNDP2 Recombinant Antibody (15E5) (CAT#: V2LY-1206-LY409)

CNDP2 Matched Antibody Pair (279) (CAT#: APMAB-279LY)

CNDP2 Matched Antibody Pair (280) (CAT#: APMAB-280LY)

Rabbit Anti-CNDP2 Recombinant Antibody (1) (CAT#: V2LY-1206-LY411)

Rabbit Anti-CNDP2 Recombinant Antibody (210) (CAT#: V2LY-1206-LY413)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry