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CNDP2

CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
Full Name
Carnosine Dipeptidase 2
Function
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245).

Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568).

Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880).

Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).
Biological Process
Glutathione biosynthetic process Source: Reactome
Proteolysis Source: GO_Central
Cellular Location
Cytoplasm
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Anti-CNDP2 antibodies

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Mouse Anti-CNDP2 Recombinant Antibody (1B1) (V2LY-1206-LY415)

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Target: CNDP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B1
Application*: E, WB
Datasheet SDS

Mouse Anti-CNDP2 Recombinant Antibody (1A6) (CBMAB-C3572-LY)

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Target: CNDP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1A6
Application*: E, WB
Datasheet SDS

Mouse Anti-CNDP2 Recombinant Antibody (CBFYC-0296) (V2LY-1206-LY414)

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Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0296
Application*: WB, IP, IF, E, F
Datasheet SDS

Rabbit Anti-CNDP2 Recombinant Antibody (210) (V2LY-1206-LY413)

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Target: CNDP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 210
Application*: P
Datasheet SDS

Rabbit Anti-CNDP2 Recombinant Antibody (1) (V2LY-1206-LY411)

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Target: CNDP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 1
Application*: E, WB
Datasheet SDS

Mouse Anti-CNDP2 Recombinant Antibody (C1327) (V2LY-1206-LY410)

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Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C1327
Application*: WB, IP
Datasheet SDS

Mouse Anti-CNDP2 Recombinant Antibody (15E5) (V2LY-1206-LY409)

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Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 15E5
Application*: WB, IF, E
Datasheet SDS

CNDP2 Matched Antibody Pair (281) (APMAB-281LY)

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Target: CNDP2
Specificity: Human
Datasheet SDS

CNDP2 Matched Antibody Pair (280) (APMAB-280LY)

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Target: CNDP2
Specificity: Human
Datasheet SDS

CNDP2 Matched Antibody Pair (279) (APMAB-279LY)

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Target: CNDP2
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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