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CNDP2

CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
Full Name
Carnosine Dipeptidase 2
Function
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245).

Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568).

Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880).

Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).
Biological Process
Glutathione biosynthetic process Source: Reactome
Proteolysis Source: GO_Central
Cellular Location
Cytoplasm

Anti-CNDP2 antibodies

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Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8A2
Application*: C, WB
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D3
Application*: IF, P, WB
Target: CNDP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 210
Application*: P
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1A6
Application*: E, WB
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16C31
Application*: E, WB
Target: CNDP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 1
Application*: E, WB
Target: CNDP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 001
Application*: WB, E
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 464702
Application*: WB, IP
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 15E5
Application*: WB, F, E
Target: CNDP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2850
Application*: WB
Target: CNDP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBWJC-2849
Application*: WB
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: AT15E5
Application*: WB, E
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-3078
Application*: WB, IH, F
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBXC-2436
Application*: WB, F, E
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-1984
Application*: E, WB
Target: CNDP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1983
Application*: P
Target: CNDP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1982
Application*: E, WB
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBFYC-0296
Application*: WB, F, E
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CAP1023
Application*: Dot blot, ELISA, WB
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PAT15E5AT
Application*: E
Target: CNDP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B1
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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