Mouse Anti-CNN1 Recombinant Antibody (CBWJC-2853) (V2LY-1206-LY437)

Name: Mouse Anti-CNN1 Recombinant Antibody (CBWJC-2853)
SKU: V2LY-1206-LY437
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-2853

Application

IHC, IF, FC

Immunogen

Crude human uterus extract.

Host Species

Mouse

Specificity

Human, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
FC	1-2 µg/10^6 cells
IF(ICC)	1-2 µg/ml
IHC-P	1-2 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.05% BSA

Preservative

0.05% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Calponin 1

Entrez Gene ID

Human

1264Rat

UniProt ID

Human	P51911
Rat	Q08290

Function

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).

Biological Process

Actomyosin structure organization Source: InterPro
Negative regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Regulation of smooth muscle contraction Source: UniProtKB

Cellular Location

Cytoskeleton; Focal adhesion

Choo, Y. Y., Sakai, T., Komatsu, S., Ikebe, R., Jeffers, A., Singh, K. P., ... & Ikebe, M. (2022). Calponin 1 contributes to myofibroblast differentiation of human pleural mesothelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology.

Mamoor, S. (2021). Differential expression of calponin 1 in cancers of the breast.

Liu, W., Fu, X., & Li, R. (2021). CNN1 regulates the DKK1/Wnt/β‑catenin/c‑myc signaling pathway by activating TIMP2 to inhibit the invasion, migration and EMT of lung squamous cell carcinoma cells. Experimental and therapeutic medicine, 22(2), 1-9.

Wang, Z., Li, T. E., Chen, M., Pan, J. J., & Shen, K. W. (2020). miR-106b-5p contributes to the lung metastasis of breast cancer via targeting CNN1 and regulating Rho/ROCK1 pathway. Aging (Albany NY), 12(2), 1867.

Feng, H. Z., Wang, H., Takahashi, K., & Jin, J. P. (2019). Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle. Journal of molecular and cellular cardiology, 129, 49-57.

Zhao, H., Yang, K., Liu, Q., Hu, J., Wu, W., & Wang, J. (2019). Expression of calponin-1 and its pathogenic role in systemic sclerosis. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 39(3), 279-285.

Cetin, O., Karaman, E., Boza, B., Cim, N., & Sahin, H. G. (2018). Maternal serum calponin 1 level as a biomarker for the short-term prediction of preterm birth in women with threatened preterm labor. The Journal of Maternal-Fetal & Neonatal Medicine, 31(2), 216-222.

Xu, H., Wu, F., Zhang, H., Yang, C., Li, K., Wang, H., ... & Dai, Z. (2017). Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity. Biochimie, 138, 184-193.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

CNN1 Matched Antibody Pair (282) (CAT#: APMAB-282LY)

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Mouse Anti-CNN1 Recombinant Antibody (CBWJC-2854) (CAT#: V2LY-1206-LY438)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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