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Mouse Anti-CNP Recombinant Antibody (11-5B) (V2LY-1206-LY481)


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Published Data
V2LY-1206-LY481-1
Mouse Anti-CNP Recombinant Antibody (11-5B) (V2LY-1206-LY481) in IF
Double immunofluorescence stainings for TNFR2 and CNPase reveal absence of TNFR2 immunoreactivity in oligodendrocytes and astrocytes in the NAWM. ...View More
Veroni, C., Serafini, B., Rosicarelli, B., Fagnani, C., Aloisi, F., & Agresti, C. (2020). Connecting immune cell infiltration to the multitasking microglia response and TNF receptor 2 induction in the multiple sclerosis brain. Frontiers in Cellular Neuroscience, 14, 190.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Rabbit, Goat, Sheep, Cattle, Cat, Dog, Pig, Monkey
Clone
11-5B
Antibody Isotype
IgG1
Application
IF, IHC-P, WB

Basic Information

Immunogen
Purified human 2'-3'-cyclic nucleotide 3'-phosphodiesterase (CNPase).
Host Species
Mouse
Specificity
Human, Mouse, Rat, Rabbit, Goat, Sheep, Cattle, Cat, Dog, Pig, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC-P1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.2% BSA
Preservative
0.1% Sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
2',3'-Cyclic Nucleotide 3' Phosphodiesterase
Entrez Gene ID
Human1267
Mouse12799
Rat25275
Dog607694
Monkey641337
UniProt ID
HumanP09543
MouseP16330
RatP13233
DogA0A5F4C1K4
MonkeyA0A2K5X8L4
Function
May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
Biological Process
Adult locomotory behavior Source: Ensembl
Aging Source: Ensembl
Axonogenesis Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Cyclic nucleotide catabolic process Source: InterPro
Forebrain development Source: Ensembl
Microtubule cytoskeleton organization Source: Ensembl
Oligodendrocyte differentiation Source: Ensembl
Regulation of mitochondrial membrane permeability Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to toxic substance Source: Ensembl
Substantia nigra development Source: UniProtKB
Cellular Location
Membrane; Melanosome. Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
More Infomation

Jo, Y. R., Kim, H. R., Jang, S. Y., Go, H., Song, M. Y., Park, D. K., ... & Park, H. T. (2021). Potential neuron‐autonomous Purkinje cell degeneration by 2′, 3′‐cyclic nucleotide 3′‐phosphodiesterase promoter/Cre‐mediated autophagy impairments. The FASEB Journal, 35(1), e21225.

Tan, K. S., Wang, D., Lu, Z., Zhang, Y., Li, S., Lin, Y., & Tan, W. (2021). CNPase, a 2’, 3’-Cyclic-nucleotide 3’-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production. International Journal of Molecular Sciences, 22(19), 10806.

Platt, D. C., Rink, J., Braich, K., McLauchlan, C. C., & Jones, M. A. (2021). 2′-3′-Cyclic Nucleotide 3′-Phosphodiesterase Inhibition by Organometallic Vanadium Complexes: A Potential New Paradigm for Studying CNS Degeneration. Brain sciences, 11(5), 588.

Duggal, Y., Kurasz, J. E., Fontaine, B. M., Marotta, N. J., Chauhan, S. S., Karls, A. C., & Weinert, E. E. (2021). Cellular Effects of 2′, 3′-Cyclic Nucleotide Monophosphates in Gram-Negative Bacteria. Journal of Bacteriology, 204(1), e00208-21.

Olga, K., Yulia, B., & Vassilios, P. (2020). The functions of mitochondrial 2′, 3′-cyclic nucleotide-3′-phosphodiesterase and prospects for its future. International Journal of Molecular Sciences, 21(9), 3217.

Unlu, I., Lu, Y., & Wang, X. (2018). The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress. Journal of Biological Chemistry, 293(50), 19365-19376.

Baburina, Y., Odinokova, I., Azarashvili, T., Akatov, V., Sotnikova, L., & Krestinina, O. (2018). Possible involvement of 2′, 3′-cyclic nucleotide-3′-phosphodiesterase in the protein phosphorylation-mediated regulation of the permeability transition pore. International Journal of Molecular Sciences, 19(11), 3499.

Fontaine, B. M., Martin, K. S., Garcia-Rodriguez, J. M., Jung, C., Briggs, L., Southwell, J. E., ... & Weinert, E. E. (2018). RNase I regulates Escherichia coli 2′, 3′-cyclic nucleotide monophosphate levels and biofilm formation. Biochemical Journal, 475(8), 1491-1506.

Baburina, Y., Odinokova, I., Azarashvili, T., Akatov, V., Lemasters, J. J., & Krestinina, O. (2017). 2′, 3′-Cyclic nucleotide 3′-phosphodiesterase as a messenger of protection of the mitochondrial function during melatonin treatment in aging. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1859(1), 94-103.

Snaidero, N., Velte, C., Myllykoski, M., Raasakka, A., Ignatev, A., Werner, H. B., ... & Simons, M. (2017). Antagonistic functions of MBP and CNP establish cytosolic channels in CNS myelin. Cell reports, 18(2), 314-323.

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For research use only. Not intended for any clinical use.

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