Mouse Anti-CNP Recombinant Antibody (CBFYC-2005) (V2LY-1206-LY488)

Name: Mouse Anti-CNP Recombinant Antibody (CBFYC-2005)
SKU: V2LY-1206-LY488
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-2005

Application

WB, FC, IHC

Immunogen

Recombinant protein corresponding to Human CNP.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	0.7-1 µg/ml
IHC	1:2,500-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 40% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

2',3'-Cyclic Nucleotide 3' Phosphodiesterase

Entrez Gene ID

Human	1267
Mouse	12799
Rat	25275

UniProt ID

Human	P09543
Mouse	P16330
Rat	P13233

Function

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.

Biological Process

Adult locomotory behavior Source: Ensembl
Aging Source: Ensembl
Axonogenesis Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Cyclic nucleotide catabolic process Source: InterPro
Forebrain development Source: Ensembl
Microtubule cytoskeleton organization Source: Ensembl
Oligodendrocyte differentiation Source: Ensembl
Regulation of mitochondrial membrane permeability Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to toxic substance Source: Ensembl
Substantia nigra development Source: UniProtKB

Cellular Location

Membrane; Melanosome. Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Jo, Y. R., Kim, H. R., Jang, S. Y., Go, H., Song, M. Y., Park, D. K., ... & Park, H. T. (2021). Potential neuron‐autonomous Purkinje cell degeneration by 2′, 3′‐cyclic nucleotide 3′‐phosphodiesterase promoter/Cre‐mediated autophagy impairments. The FASEB Journal, 35(1), e21225.

Tan, K. S., Wang, D., Lu, Z., Zhang, Y., Li, S., Lin, Y., & Tan, W. (2021). CNPase, a 2’, 3’-Cyclic-nucleotide 3’-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production. International Journal of Molecular Sciences, 22(19), 10806.

Platt, D. C., Rink, J., Braich, K., McLauchlan, C. C., & Jones, M. A. (2021). 2′-3′-Cyclic Nucleotide 3′-Phosphodiesterase Inhibition by Organometallic Vanadium Complexes: A Potential New Paradigm for Studying CNS Degeneration. Brain sciences, 11(5), 588.

Duggal, Y., Kurasz, J. E., Fontaine, B. M., Marotta, N. J., Chauhan, S. S., Karls, A. C., & Weinert, E. E. (2021). Cellular Effects of 2′, 3′-Cyclic Nucleotide Monophosphates in Gram-Negative Bacteria. Journal of Bacteriology, 204(1), e00208-21.

Olga, K., Yulia, B., & Vassilios, P. (2020). The functions of mitochondrial 2′, 3′-cyclic nucleotide-3′-phosphodiesterase and prospects for its future. International Journal of Molecular Sciences, 21(9), 3217.

Unlu, I., Lu, Y., & Wang, X. (2018). The cyclic phosphodiesterase CNP and RNA cyclase RtcA fine-tune noncanonical XBP1 splicing during ER stress. Journal of Biological Chemistry, 293(50), 19365-19376.

Baburina, Y., Odinokova, I., Azarashvili, T., Akatov, V., Sotnikova, L., & Krestinina, O. (2018). Possible involvement of 2′, 3′-cyclic nucleotide-3′-phosphodiesterase in the protein phosphorylation-mediated regulation of the permeability transition pore. International Journal of Molecular Sciences, 19(11), 3499.

Fontaine, B. M., Martin, K. S., Garcia-Rodriguez, J. M., Jung, C., Briggs, L., Southwell, J. E., ... & Weinert, E. E. (2018). RNase I regulates Escherichia coli 2′, 3′-cyclic nucleotide monophosphate levels and biofilm formation. Biochemical Journal, 475(8), 1491-1506.

Baburina, Y., Odinokova, I., Azarashvili, T., Akatov, V., Lemasters, J. J., & Krestinina, O. (2017). 2′, 3′-Cyclic nucleotide 3′-phosphodiesterase as a messenger of protection of the mitochondrial function during melatonin treatment in aging. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1859(1), 94-103.

Snaidero, N., Velte, C., Myllykoski, M., Raasakka, A., Ignatev, A., Werner, H. B., ... & Simons, M. (2017). Antagonistic functions of MBP and CNP establish cytosolic channels in CNS myelin. Cell reports, 18(2), 314-323.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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