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Rabbit Anti-CNTN5 Recombinant Antibody (024) (V2LY-1206-LY545)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
024
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human Contactin 5 / CNTN5 Protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Contactin 5
Entrez Gene ID
53942
UniProt ID
O94779
Function
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).
Biological Process
Cell adhesion Source: UniProtKB-KW
Presynapse assembly Source: Ensembl
Sensory perception of sound Source: Ensembl
Cellular Location
Cell membrane
More Infomation

Schmilovich, Z., Huguet, G., He, Q., Musa-Johnson, A., Douard, E., Loum, M. A., ... & Rouleau, G. A. (2021). Copy-Number Variants in The Contactin-5 Gene Are a Potential Risk Factor for Autism Spectrum Disorder.

Dauar, M. T., Picard, C., Rosa‐Neto, P., Villeneuve, S., Poirier, J., & Prevent‐AD Research Group. (2021). CNTN5 is associated with disease risk and pathology throughout the Alzheimer’s disease continuum. Alzheimer's & Dementia, 17, e052359.

Kleijer, K. T., van Nieuwenhuize, D., Spierenburg, H. A., Gregorio-Jordan, S., Kas, M. J., & Burbach, J. P. H. (2018). Structural abnormalities in the primary somatosensory cortex and a normal behavioral profile in Contactin-5 deficient mice. Cell Adhesion & Migration, 12(1), 5-18.

Smirnov, A. V., Kontsevaya, G. V., Feofanova, N. A., Anisimova, M. V., Serova, I. A., Gerlinskaya, L. A., ... & Serov, O. L. (2018). Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice. Transgenic research, 27(1), 1-13.

Peng, Y. R., Tran, N. M., Krishnaswamy, A., Kostadinov, D., Martersteck, E. M., & Sanes, J. R. (2017). Satb1 regulates contactin 5 to pattern dendrites of a mammalian retinal ganglion cell. Neuron, 95(4), 869-883.

Oguro-Ando, A., Zuko, A., Kleijer, K. T., & Burbach, J. P. H. (2017). A current view on contactin-4,-5, and-6: Implications in neurodevelopmental disorders. Molecular and Cellular Neuroscience, 81, 72-83.

Smirnov, A. V., Feofanova, N. A., Kontsevaya, G. V., Anisimova, M. V., Kovrigin, I. I., Serova, I. A., ... & Battulin, N. R. (2017). Morphophysiological effects of insertional mutagenesis of the contactin 5 (Cntn5) gene in transgenic mice. Russian Journal of Genetics: Applied Research, 7(8), 799-805.

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For research use only. Not intended for any clinical use.

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