Rat Anti-CPA1 Recombinant Antibody (CBXC-2236) (V2LY-1206-LY903)

Name: Rat Anti-CPA1 Recombinant Antibody (CBXC-2236)
SKU: V2LY-1206-LY903
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXC-2236

Application

WB, IP

Immunogen

Recombinant human Carboxypeptidase A1/CPA1 Lys17-Tyr419.

Host Species

Rat

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1 µg/ml
IP	25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Carboxypeptidase A1

Entrez Gene ID

1357

UniProt ID

P15085

Function

Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (PubMed:8806703).

Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity).

Biological Process

Leukotriene metabolic process Source: UniProtKB
Proteolysis Source: GO_Central

Cellular Location

Secreted

Uhlig, R., Contreras, H., Weidemann, S., Gorbokon, N., Menz, A., Büscheck, F., ... & Clauditz, T. S. (2022). Carboxypeptidase A1 (CPA1) immunohistochemistry is highly sensitive and specific for acinar cell carcinoma (ACC) of the pancreas. The American journal of surgical pathology, 46(1), 97-104.

Wang, W., Tang, W., Wang, X., Liu, W., & Zhu, F. (2022). Genes from Carboxypeptidase A, glutathione S-transferase, and cytochrome b families were found involved in lead transport in insect Musca domestica. Ecotoxicology and Environmental Safety, 230, 113113.

Naureen, U., Arif, R., Akram, F., Shahid, M. G., & Saleem, M. (2021). Genetic Diversity Analysis and In Silico Investigation of Post-Translational Modifications of Carboxypeptidase A1 (CpA1) in Sordaria fimicola. International Journal of Agriculture and Biology, 25(2), 475-482.

Said, S., Kurtin, P. J., Nasr, S. H., Graham, R. P., Dasari, S., Vrana, J. A., ... & Wu, T. T. (2020). Carboxypeptidase A1 and regenerating islet-derived 1α as new markers for pancreatic acinar cell carcinoma. Human Pathology, 103, 120-126.

Orekhova, A., Geisz, A., & Sahin-Tóth, M. (2020). Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(4), G694-G704.

Hegyi, E., & Sahin-Tóth, M. (2019). Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice. Gut, 68(2), 301-312.

Tamura, K., Yu, J., Hata, T., Suenaga, M., Shindo, K., Abe, T., ... & Goggins, M. (2018). Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proceedings of the National Academy of Sciences, 115(18), 4767-4772.

Wu, H., Zhou, D. Z., Berki, D., Geisz, A., Zou, W. B., Sun, X. T., ... & Liao, Z. (2017). No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort. Human mutation, 38(8), 959-963.

Kujko, A. A., Berki, D. M., Oracz, G., Wejnarska, K., Antoniuk, J., Wertheim-Tysarowska, K., ... & Rygiel, A. M. (2017). A novel p. Ser282Pro CPA1 variant is associated with autosomal dominant hereditary pancreatitis. Gut, 66(9), 1728-1730.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CPA1 Matched Antibody Pair (292) (CAT#: APMAB-292LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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