Mouse Recombinant CPA1 protein, His Tag (V2LY-0526-LY7914)

Name: Mouse Recombinant CPA1 protein, His Tag
SKU: V2LY-0526-LY7914
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant CPA1 protein, His Tag consist of Amino Acid: 1-419 and predicts a molecular mass of 47 kDa.

Molecule Mass

47 kDa

Sequence

Amino Acid: 1-419

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>96% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Carboxypeptidase A1

Function

Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (PubMed:8806703).

Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity).

Biological Process

Leukotriene metabolic process Source: UniProtKB
Proteolysis Source: GO_Central

Cellular Location

Secreted

Uhlig, R., Contreras, H., Weidemann, S., Gorbokon, N., Menz, A., Büscheck, F., ... & Clauditz, T. S. (2022). Carboxypeptidase A1 (CPA1) immunohistochemistry is highly sensitive and specific for acinar cell carcinoma (ACC) of the pancreas. The American journal of surgical pathology, 46(1), 97-104.

Wang, W., Tang, W., Wang, X., Liu, W., & Zhu, F. (2022). Genes from Carboxypeptidase A, glutathione S-transferase, and cytochrome b families were found involved in lead transport in insect Musca domestica. Ecotoxicology and Environmental Safety, 230, 113113.

Naureen, U., Arif, R., Akram, F., Shahid, M. G., & Saleem, M. (2021). Genetic Diversity Analysis and In Silico Investigation of Post-Translational Modifications of Carboxypeptidase A1 (CpA1) in Sordaria fimicola. International Journal of Agriculture and Biology, 25(2), 475-482.

Said, S., Kurtin, P. J., Nasr, S. H., Graham, R. P., Dasari, S., Vrana, J. A., ... & Wu, T. T. (2020). Carboxypeptidase A1 and regenerating islet-derived 1α as new markers for pancreatic acinar cell carcinoma. Human Pathology, 103, 120-126.

Orekhova, A., Geisz, A., & Sahin-Tóth, M. (2020). Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(4), G694-G704.

Hegyi, E., & Sahin-Tóth, M. (2019). Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice. Gut, 68(2), 301-312.

Tamura, K., Yu, J., Hata, T., Suenaga, M., Shindo, K., Abe, T., ... & Goggins, M. (2018). Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proceedings of the National Academy of Sciences, 115(18), 4767-4772.

Wu, H., Zhou, D. Z., Berki, D., Geisz, A., Zou, W. B., Sun, X. T., ... & Liao, Z. (2017). No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort. Human mutation, 38(8), 959-963.

Kujko, A. A., Berki, D. M., Oracz, G., Wejnarska, K., Antoniuk, J., Wertheim-Tysarowska, K., ... & Rygiel, A. M. (2017). A novel p. Ser282Pro CPA1 variant is associated with autosomal dominant hereditary pancreatitis. Gut, 66(9), 1728-1730.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

CPA1 Matched Antibody Pair (292) (CAT#: APMAB-292LY)

Antibody Pairs

CPA1 Matched Antibody Pair (292) (CAT#: APMAB-292LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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