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Rat Anti-CRISP1 Recombinant Antibody (CBYY-C0678) (CBMAB-C2001-YY)

This product is rat antibody that recognizes CRISP1. The antibody CBYY-C0678 can be used for immunoassay techniques such as: WB, IHC, Neut
See all CRISP1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-C0678
Antibody Isotype
IgG2b
Application
WB, IHC, Neut

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse CRISP-1, Gln20-His244, Accession # Q03401
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A/G purified
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cysteine Rich Secretory Protein 1
Entrez Gene ID
11571
UniProt ID
Q03401
Alternative Names
Caspase 4; Caspase 4, Apoptosis-Related Cysteine Peptidase; Caspase 4, Apoptosis-Related Cysteine Protease; ICE And Ced-3 Homolog 2; Protease TX; ICE(Rel)-II; CASP-4; ICH-2; Mih1; Apoptotic Cysteine Protease Mih1/TX;
Function
May have a role in sperm-egg fusion and maturation.
Biological Process
Binding of sperm to zona pellucida Source: GO_Central
Fusion of sperm to egg plasma membrane involved in single fertilization Source: ProtInc

Kumar, S., Leeb, A. S., Vaughan, A. M., & Kappe, S. H. (2022). A Plasmodium falciparum Cysteine Rich Secretory protein uniquely localizes to one end of male gametes. Molecular and Biochemical Parasitology, 111447.

Jorasia, K., Paul, R. K., Rathore, N. S., Lal, P., Singh, R., & Sareen, M. (2021). Production of bioactive recombinant ovine cysteine-rich secretory protein 1 in Escherichia coli. Systems biology in reproductive medicine, 67(6), 471-481.

Arévalo, L., Brukman, N. G., Cuasnicú, P. S., & Roldan, E. R. (2020). Evolutionary analysis of genes coding for Cysteine-RIch Secretory Proteins (CRISPs) in mammals. BMC evolutionary biology, 20(1), 1-13.

Bernardes, C. P., Menaldo, D. L., Zoccal, K. F., Boldrini-Franca, J., Peigneur, S., Arantes, E. C., ... & Sampaio, S. V. (2019). First report on BaltCRP, a cysteine-rich secretory protein (CRISP) from Bothrops alternatus venom: effects on potassium channels and inflammatory processes. International journal of biological macromolecules, 140, 556-567.

Weigel Muñoz, M., Battistone, M. A., Carvajal, G., Maldera, J. A., Curci, L., Torres, P., ... & Cuasnicú, P. S. (2018). Influence of the genetic background on the reproductive phenotype of mice lacking Cysteine-Rich Secretory Protein 1 (CRISP1). Biology of Reproduction, 99(2), 373-383.

Lodovicho, M. E., Costa, T. R., Bernardes, C. P., Menaldo, D. L., Zoccal, K. F., Carone, S. E., ... & Sampaio, S. V. (2017). Investigating possible biological targets of Bj-CRP, the first cysteine-rich secretory protein (CRISP) isolated from Bothrops jararaca snake venom. Toxicology letters, 265, 156-169.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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