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Mouse Anti-CRLF2 Recombinant Antibody (CBYY-C2865) (V2LY-1206-LY1201)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2865
Antibody Isotype
IgG2a, κ
Application
FC, WB

Basic Information

Immunogen
A partial length recombinant TSLPR protein (aa 97-252).
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB2-4 µg/ml
FC0.5-1 µg/10^6 Cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% Glycerol, 0.05% BSA
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytokine Receptor Like Factor 2
Entrez Gene ID
64109
UniProt ID
Q9HC73
Function
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity).

Implicated in the development of the hematopoietic system.
Biological Process
Cytokine-mediated signaling pathway Source: UniProtKB
Interleukin-7-mediated signaling pathway Source: Reactome
Oncostatin-M-mediated signaling pathway Source: GOC
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of interleukin-5 production Source: UniProtKB
Positive regulation of mast cell activation Source: UniProtKB
Positive regulation of receptor signaling pathway via STAT Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Topology
Extracellular: 23-231
Helical: 232-252
Cytoplasmic: 253-371
More Infomation

Rasekh, E. O., Atef, A. M., Khalil, M., Ebeid, E., Madney, Y., & Hamdy, N. (2021). Characterization of CRLF2 Expression in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia. Clinical Laboratory, 67(1).

Mohamed, S. M., Wohlmann, A., Schofield, P., Sia, K. C., McCalmont, H., Savvides, S. N., ... & Lock, R. B. (2021). A recombinant antibody fragment directed to the thymic stromal lymphopoietin receptor (CRLF2) efficiently targets pediatric Philadelphia chromosome-like acute lymphoblastic leukemia. International Journal of Biological Macromolecules, 190, 214-223.

Moreno-Lorenzana, D., Juárez-Velázquez, R., Martínez-Anaya, D., & Péez-Vera, P. (2020). CRLF2 (cytokine receptor like factor 2). Atlas of Genetics and Cytogenetics in Oncology and Haematology.

Meyer, L. K., Delgado-Martin, C., Maude, S. L., Shannon, K. M., Teachey, D. T., & Hermiston, M. L. (2019). CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition. PloS one, 14(7), e0220026.

Zhang, Q., Shi, C., Han, L., Jain, N., Roberts, K. G., Ma, H., ... & Konopleva, M. (2018). Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome–like acute B-cell lymphoblastic leukemia. Oncotarget, 9(8), 8027.

Pastorczak, A., Sedek, L., Braun, M., Madzio, J., Sonsala, A., Twardoch, M., ... & Młynarski, W. (2018). Surface expression of Cytokine Receptor-Like Factor 2 increases risk of relapse in pediatric acute lymphoblastic leukemia patients harboring IKZF1 deletions. Oncotarget, 9(40), 25971.

Mangaonkar, A., Patnaik, M. M., Kaiser-Rogers, K., Rao, K. W., Halling, K., Oliver, G., ... & Van Dyke, D. L. (2017). Cytokine Receptor-like Factor 2 (CRLF2) Overexpression in Myeloid Malignancies Secondary to Multiple Isodicentric Y Chromosomes: A Novel Cytogenetic Entity?. Blood, 130, 1702.

Konoplev, S., Lu, X., Konopleva, M., Jain, N., Ouyang, J., Goswami, M., ... & Wang, S. A. (2017). CRLF2-Positive B-Cell Acute Lymphoblastic Leukemia in Adult PatientsA Single-Institution Experience. American journal of clinical pathology, 147(4), 357-363.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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