CRLF2
CRLF2 (Cytokine Receptor Like Factor 2) is a Protein Coding gene. Diseases associated with CRLF2 include Lymphoblastic Leukemia, Acute, With Lymphomatous Features and Lymphoblastic Leukemia. Among its related pathways are Th2 Differentiation Pathway and Jak-STAT signaling pathway (KEGG).
Full Name
Cytokine Receptor Like Factor 2
Function
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity).
Implicated in the development of the hematopoietic system.
Implicated in the development of the hematopoietic system.
Biological Process
Cytokine-mediated signaling pathway Source: UniProtKB
Interleukin-7-mediated signaling pathway Source: Reactome
Oncostatin-M-mediated signaling pathway Source: GOC
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of interleukin-5 production Source: UniProtKB
Positive regulation of mast cell activation Source: UniProtKB
Positive regulation of receptor signaling pathway via STAT Source: UniProtKB
Interleukin-7-mediated signaling pathway Source: Reactome
Oncostatin-M-mediated signaling pathway Source: GOC
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of interleukin-5 production Source: UniProtKB
Positive regulation of mast cell activation Source: UniProtKB
Positive regulation of receptor signaling pathway via STAT Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 2: Secreted
Topology
Extracellular: 23-231
Helical: 232-252
Cytoplasmic: 253-371
Helical: 232-252
Cytoplasmic: 253-371
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Anti-CRLF2 antibodies
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CompareTarget: CRLF2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1153
Application*: WB, E
Target: CRLF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-233
Tag: hFc Tag
Target: CRLF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-231
Tag: His Tag
Target: CRLF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-231
Tag: His Tag
Target: CRLF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-231
Tag: hFc Tag
Target: CRLF2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-231
Tag: hFc Tag
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3174
Application*: IH, F
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C2865
Application*: F, WB
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-1156
Application*: F, B
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1154
Application*: WB
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1152
Application*: F, WB
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-1151
Application*: F, WB
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1150
Application*: F, WB
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-1149
Application*: WB, P
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2216
Application*: E, IP, WB
Target: CRLF2
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBWJC-3093
Application*: WB, F, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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