CRLF2

CRLF2 (Cytokine Receptor Like Factor 2) is a Protein Coding gene. Diseases associated with CRLF2 include Lymphoblastic Leukemia, Acute, With Lymphomatous Features and Lymphoblastic Leukemia. Among its related pathways are Th2 Differentiation Pathway and Jak-STAT signaling pathway (KEGG).

Cytokine Receptor Like Factor 2

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity).

Implicated in the development of the hematopoietic system.

Cytokine-mediated signaling pathway Source: UniProtKB
Interleukin-7-mediated signaling pathway Source: Reactome
Oncostatin-M-mediated signaling pathway Source: GOC
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of interleukin-5 production Source: UniProtKB
Positive regulation of mast cell activation Source: UniProtKB
Positive regulation of receptor signaling pathway via STAT Source: UniProtKB

Isoform 1: Cell membrane
Isoform 2: Secreted

Extracellular: 23-231
Helical: 232-252
Cytoplasmic: 253-371