Mouse Anti-CSF2RB Recombinant Antibody (CBXC-1906) (V2LY-1206-LY1462)

Name: Mouse Anti-CSF2RB Recombinant Antibody (CBXC-1906)
SKU: V2LY-1206-LY1462
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-1906

Application

WB, IHC-P, ELISA, FC

Immunogen

Purified recombinant fragment of human CD131 (AA: extra 17-149) expressed in E. Coli.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:10,000
WB	1:500-1:2,000
FC	1:200-1:400
IHC-P	1:200-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.05% sodium azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Colony Stimulating Factor 2 Receptor Beta Common Subunit

Entrez Gene ID

Human	1439
Mouse	12983

UniProt ID

Human	P32927
Mouse	P26955

Function

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

Biological Process

Cellular protein metabolic process Source: Reactome
Cellular response to interleukin-3 Source: GOC
Cytokine-mediated signaling pathway Source: Reactome
Interleukin-3-mediated signaling pathway Source: GOC
Interleukin-5-mediated signaling pathway Source: GOC
MAPK cascade Source: Reactome
Respiratory gaseous exchange by respiratory system Source: ProtInc
Response to lipopolysaccharide Source: Ensembl
Signal transduction Source: UniProtKB

Cellular Location

Membrane

Involvement in disease

Pulmonary surfactant metabolism dysfunction 5 (SMDP5):
A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

Topology

Extracellular: 17-443
Helical: 444-460
Cytoplasmic: 461-897

PTM

May be phosphorylated by LYN.

Rashid, M., Ali, R., Almuzzaini, B., Song, H., AlHallaj, A., Abdulkarim, A. A., ... & Boudjelal, M. (2021). Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer. Cancer medicine, 10(22), 8138-8150.

Schulte, V., Sipol, A., Burdach, S., & Rieger-Fackeldey, E. (2021). The Truncated Splice Variant of the Granulocyte-Macrophage-Colony-Stimulating Factor Receptor β-Chain in Peripheral Blood Serves as Severity Biomarker of Respiratory Failure in Newborns. Neonatology, 118(2), 187-193.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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