Mouse Anti-CSNK1G1 Recombinant Antibody (4F12) (V2LY-0125-LY24)

Name: Mouse Anti-CSNK1G1 Recombinant Antibody (4F12)
SKU: V2LY-0125-LY24
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

4F12

Antibody Isotype

IgG2a

Application

Basic Information

Immunogen

Human recombinant protein fragment corresponding to amino acids 163-422 of human CSNK1G1 produced in E. coli.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA, Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Casein Kinase 1 Gamma 1

Entrez Gene ID

53944

UniProt ID

Q9HCP0

Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).

Phosphorylates CLSPN.

Biological Process

Endocytosis Source: GO_Central
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Wnt signaling pathway Source: GO_Central

Cellular Location

Cytoplasm

PTM

Autophosphorylated.

More Infomation

References

Chen, H., Li, Q., Yi, R., Li, B., Xiong, D., & Peng, H. (2022). CircRNA casein kinase 1 gamma 1 (circ‐CSNK1G1) plays carcinogenic effects in thyroid cancer by acting as miR‐149‐5p sponge and relieving the suppression of miR‐149‐5p on mitogen‐activated protein kinase 1 (MAPK1). Journal of clinical laboratory analysis, e24188.

Agajanian, M. J., Potjewyd, F. M., Bowman, B. M., Solomon, S., LaPak, K. M., Bhatt, D. P., ... & Major, M. B. (2021). Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling. bioRxiv.

Gold, N. B., Li, D., Chassevent, A., Kaiser, F. J., Parenti, I., Strom, T. M., ... & Bhoj, E. (2020). Heterozygous de novo variants in CSNK1G1 are associated with syndromic developmental delay and autism spectrum disorder. Clinical Genetics, 98(6), 571-576.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

CSNK1G1 Matched Antibody Pair (305)

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CSNK1G1 Matched Antibody Pair (305)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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