Mouse Anti-CST3 Recombinant Antibody (CBT2479) (V2LY-0625-LY2628)

Name: Mouse Anti-CST3 Recombinant Antibody (CBT2479)
SKU: V2LY-0625-LY2628
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CST3 Recombinant Antibody (CBT2479) (V2LY-0625-LY2628) in WB

Mouse Anti-CST3 Recombinant Antibody (CBT2479) (V2LY-0625-LY2628) in ELISA

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2479

Application

Immunogen

Purified recombinant fragment of human CST3 expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cystatin C

Entrez Gene ID

1471

UniProt ID

P01034

Alternative Names

Cystatin C; Neuroendocrine Basic Polypeptide; Post-Gamma-Globulin; Gamma-Trace; Cystatin C (Amyloid Angiopathy And Cerebral Hemorrhage); Epididymis Secretory Protein Li 2; BA218C14.4 (Cystatin C);

Function

As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

Biological Process

Amyloid fibril formation Source: Reactome
Cellular protein metabolic process Source: Reactome
Defense response Source: BHF-UCL
Negative regulation of blood vessel remodeling Source: BHF-UCL
Negative regulation of collagen catabolic process Source: BHF-UCL
Negative regulation of elastin catabolic process Source: BHF-UCL
Negative regulation of extracellular matrix disassembly Source: BHF-UCL
Negative regulation of peptidase activity Source: ARUK-UCL
Negative regulation of proteolysis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Post-translational protein modification Source: Reactome
Regulation of tissue remodeling Source: BHF-UCL
Supramolecular fiber organization Source: BHF-UCL

Cellular Location

Secreted

Involvement in disease

Amyloidosis 6 (AMYL6):
A hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.
Macular degeneration, age-related, 11 (ARMD11):
A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

PTM

The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21.

Zhang, X., Liu, X., Su, G., Li, M., Liu, J., Wang, C., & Xu, D. (2021). pH-dependent and dynamic interactions of cystatin C with heparan sulfate. Communications biology, 4(1), 1-11.

Christopher, J. R., Ponnaiyan, D., Parthasarathy, H., & Tadepalli, A. (2021). Association of CST3 Gene with Its Protein: Cystatin C in Health and Severe Periodontal Disease. Genetic Testing and Molecular Biomarkers, 25(6), 405-410.

Indacochea, A., Guerrero, S., Ureña, M., Araujo, F., Coll, O., LLeonart, M. E., & Gebauer, F. (2021). Cold-inducible RNA binding protein promotes breast cancer cell malignancy by regulating Cystatin C levels. Rna, 27(2), 190-201.

Tahir, N. A. M., Saffian, S. M., Islahudin, F. H., Gafor, A. H. A., Othman, H., Manan, H. A., & Makmor-Bakry, M. (2020). Effects of CST3 Gene G73A Polymorphism on Cystatin C in a Prospective Multiethnic Cohort Study. Nephron, 144(4), 204-212.

Hoghooghi, V., Palmer, A. L., Frederick, A., Jiang, Y., Merkens, J. E., Balakrishnan, A., ... & Ousman, S. S. (2020). Cystatin C Plays a Sex-Dependent Detrimental Role in Experimental Autoimmune Encephalomyelitis. Cell reports, 33(1), 108236.

Maniwa, K., Yano, S., Sheikh, A. M., Onoda, K., Mitaki, S., Isomura, M., ... & Nagai, A. (2020). Association between cystatin C gene polymorphism and the prevalence of white matter lesion in elderly healthy subjects. Scientific Reports, 10(1), 1-9.

Huda, M. N., VerHague, M., Albright, J., Smallwood, T., Bell, T. A., Que, E., ... & Bennett, B. J. (2020). Dissecting the genetic architecture of cystatin C in Diversity Outbred mice. G3: Genes, Genomes, Genetics, 10(7), 2529-2541.

Zeng, Q., Huang, Z., Wei, L., Fang, J., & Lin, K. (2019). Correlations of serum cystatin C level and gene polymorphism with vascular cognitive impairment after acute cerebral infarction. Neurological Sciences, 40(5), 1049-1054.

Lee, R. K. K., Tseng, H. C., Hwu, Y. M., Fan, C. C., Lin, M. H., Yu, J. J., ... & Li, S. H. (2018). Expression of cystatin C in the female reproductive tract and its effect on human sperm capacitation. Reproductive Biology and Endocrinology, 16(1), 1-10.

Li, Z., Wang, S., Huo, X., Yu, H., Lu, J., Zhang, S., ... & Chen, Z. (2018). Cystatin C expression is promoted by VEGFA blocking, with inhibitory effects on endothelial cell angiogenic functions including proliferation, migration, and chorioallantoic membrane angiogenesis. Journal of the American Heart Association, 7(21), e009167.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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