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CST3

CST3 (Cystatin C) is a Protein Coding gene. Diseases associated with CST3 include Cerebral Amyloid Angiopathy, Cst3-Related and Macular Degeneration, Age-Related, 11. Among its related pathways are Innate Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include identical protein binding and endopeptidase inhibitor activity. An important paralog of this gene is CST2.
Full Name
Cystatin C
Function
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Biological Process
Amyloid fibril formation Source: Reactome
Cellular protein metabolic process Source: Reactome
Defense response Source: BHF-UCL
Negative regulation of blood vessel remodeling Source: BHF-UCL
Negative regulation of collagen catabolic process Source: BHF-UCL
Negative regulation of elastin catabolic process Source: BHF-UCL
Negative regulation of extracellular matrix disassembly Source: BHF-UCL
Negative regulation of peptidase activity Source: ARUK-UCL
Negative regulation of proteolysis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Post-translational protein modification Source: Reactome
Regulation of tissue remodeling Source: BHF-UCL
Supramolecular fiber organization Source: BHF-UCL
Cellular Location
Secreted
Involvement in disease
Amyloidosis 6 (AMYL6):
A hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.
Macular degeneration, age-related, 11 (ARMD11):
A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
PTM
The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21.

Anti-CST3 antibodies

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Target: CST3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: 678920
Application*: C, IP
Target: CST3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 4E59
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3258
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3256
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: Cyst-10
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3254
Application*: WB, F
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3253
Application*: WB, IH
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-3250
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1733
Application*: WB, IP, IF, E
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1728
Application*: WB, IP, E
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1002
Application*: ED
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-3036
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2723
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1907
Application*: WB, IF
Target: CST3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1499
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0597
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1001
Application*: IH, EC
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Cyst24
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: V2-263156
Application*: WB, E
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 041
Application*: E
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 002
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP580
Application*: ELISA, IHC
Target: CST3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYR0659
Application*: SE
Target: CST3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0658
Application*: SE
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB171A
Application*: ELISA, IHC
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8H7
Application*: ELISA
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8D1
Application*: ELISA
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-2333
Application*: IP, WB
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2332
Application*: P
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-2331
Application*: E
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYC-2330
Application*: P
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYC-2329
Application*: E
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-2328
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2326
Application*: IF, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYC-2325
Application*: E, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYC-2324
Application*: WB, P
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP583
Application*: ICC, IHC, IP, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP582
Application*: ICC, IHC, IP, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CAP581
Application*: ICC, IHC, IP, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8J182
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human
Clone: CBFYC-2334
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F12-C7-D8
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L338
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C3084
Application*: WB, P
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2265
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2256
Application*: S-E
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2255
Application*: WB, P
Target: CST3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4H8
Application*: ELISA, FC, IHC-P, WB
Target: CST3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0216-4E59
Application*: WB
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 41
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0229-3N39
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3A1B7
Application*: E, IH
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBCNC-427
Application*: E, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBCNC-426
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-425
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-424
Application*: P
Target: CST3
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBCNC-421
Application*: E
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D6U3E
Application*: WB, IP
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9L818
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B2630
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 10B2631
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 11H29
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-C2239
Application*: WB, P
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2238
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2234
Application*: WB, P
Target: CST3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C2224
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2215
Application*: WB, E
Target: CST3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-C2212
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2203
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8J178
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7B8
Application*: C, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H2
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 5F4H6
Application*: WB, P
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C3-C7
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5A2
Application*: WB, P
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 572CT4.3.2
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B10C9H9
Application*: WB, E
Target: CST3
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: Cyst10
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Cyst19
Application*: E, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Cyst20
Application*: E, C
Target: CST3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: Cyst29
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 197807
Application*: WB, IP
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 001
Application*: E
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 033
Application*: P
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 11H3C12
Application*: WB, P
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 13
Application*: E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B202
Application*: E, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 13F37
Application*: E, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 15j64
Application*: E, C, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A6
Application*: IF, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7G8
Application*: F, WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F12A10C12
Application*: WB, E
Target: CST3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H4
Application*: WB, E
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C11
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C8
Application*: WB, IH, P
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5F1
Application*: WB, P
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2G4
Application*: E
Target: CST3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 33
Application*: P
Target: CST3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3B12
Application*: WB
Target: CST3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D10
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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