Mouse Anti-CTBP1 Recombinant Antibody (C5442) (V2LY-0125-LY212)

Name: Mouse Anti-CTBP1 Recombinant Antibody (C5442)
SKU: V2LY-0125-LY212
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

C5442

Antibody Isotype

IgG1

Application

WB, IF, IHC-P

Basic Information

Immunogen

CTBP1 Fusion Protein.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC-P	1:2,000
WB	1:15,000
IF(ICC)	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

C-Terminal Binding Protein 1

Entrez Gene ID

Human	1487
Mouse	13016
Rat	29382
Chicken	422904
Dog	612240

UniProt ID

Human	Q13363
Mouse	O88712
Rat	Q9Z2F5
Chicken	A0A1D5P770
Dog	F1P620

Function

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Biological Process

Chromatin silencing Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of histone acetylation Source: BHF-UCL
Negative regulation of histone H4 acetylation Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of histone deacetylation Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell cycle Source: BHF-UCL
Viral genome replication Source: ProtInc
White fat cell differentiation Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus

Involvement in disease

Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome (HADDTS):
An autosomal dominant disorder characterized by delayed motor development, intellectual disability, failure to thrive, hypotonia, ataxia, and tooth enamel defects.

PTM

The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
ADP-ribosylated; when cells are exposed to brefeldin A.
Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.

More Infomation

References

Deng, Y., Guo, W., Xu, N., Li, F., & Li, J. (2020). CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells. Molecular Carcinogenesis, 59(5), 512-519.

Deng, Y., Guo, W., Li, G., Li, S., Li, H., Li, X., ... & Li, F. (2020). Protocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1. Journal of Breast Cancer, 23(1), 20-35.

Cousins, S. L., & Stephenson, F. A. (2019). Identification of C-terminal binding protein 1 as a novel NMDA receptor interactor. Neurochemical Research, 44(6), 1437-1445.

Deng, Y., Li, H., Yin, X., Liu, H., Liu, J., Guo, D., & Shi, Z. (2018). C-terminal binding protein 1 modulates cellular redox via feedback regulation of MPC1 and MPC2 in melanoma cells. Medical science monitor: international medical journal of experimental and clinical research, 24, 7614.

Bellesis, A. G., Jecrois, A. M., Hayes, J. A., Schiffer, C. A., & Royer, W. E. (2018). Assembly of human C-terminal binding protein (CtBP) into tetramers. Journal of Biological Chemistry, 293(23), 9101-9112.

Colomer, J., De, B., Ortez, C., Jou, C., Jiménez-Mallebrera, C., Olivé, M., ... & Nascimento, A. (2017). C-terminal binding protein 1 (CtBP1) deficiency, mimicking congenital myopathy during infancy. Neuromuscular Disorders, 27, S186.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

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SDS
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Second antibody and isotype control

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