Mouse Anti-CTBP1 Recombinant Antibody (CAP1025) (CBMAB-AP1759LY)

Name: Mouse Anti-CTBP1 Recombinant Antibody (CAP1025)
SKU: CBMAB-AP1759LY
Rating: 5 (1 reviews)

See all CTBP1 antibodies

Online Inquiry

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CAP1025

Antibody Isotype

IgG2a, κ

Application

IP, IHC, WB

Basic Information

Immunogen

Full length protein with C-terminal 6xHis-tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.05% sodium azide

Concentration

4 mg/ml

Target

Full Name

C-Terminal Binding Protein 1

Entrez Gene ID

1487

UniProt ID

Q13363

Function

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Biological Process

Chromatin silencing Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of histone acetylation Source: BHF-UCL
Negative regulation of histone H4 acetylation Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of histone deacetylation Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell cycle Source: BHF-UCL
Viral genome replication Source: ProtInc
White fat cell differentiation Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus

Involvement in disease

Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome (HADDTS):
An autosomal dominant disorder characterized by delayed motor development, intellectual disability, failure to thrive, hypotonia, ataxia, and tooth enamel defects.

PTM

The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
ADP-ribosylated; when cells are exposed to brefeldin A.
Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.

More Infomation

References

Deng, Y., Guo, W., Xu, N., Li, F., & Li, J. (2020). CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells. Molecular Carcinogenesis, 59(5), 512-519.

Deng, Y., Guo, W., Li, G., Li, S., Li, H., Li, X., ... & Li, F. (2020). Protocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1. Journal of Breast Cancer, 23(1), 20-35.

Cousins, S. L., & Stephenson, F. A. (2019). Identification of C-terminal binding protein 1 as a novel NMDA receptor interactor. Neurochemical Research, 44(6), 1437-1445.

Deng, Y., Li, H., Yin, X., Liu, H., Liu, J., Guo, D., & Shi, Z. (2018). C-terminal binding protein 1 modulates cellular redox via feedback regulation of MPC1 and MPC2 in melanoma cells. Medical science monitor: international medical journal of experimental and clinical research, 24, 7614.

Bellesis, A. G., Jecrois, A. M., Hayes, J. A., Schiffer, C. A., & Royer, W. E. (2018). Assembly of human C-terminal binding protein (CtBP) into tetramers. Journal of Biological Chemistry, 293(23), 9101-9112.

Colomer, J., De, B., Ortez, C., Jou, C., Jiménez-Mallebrera, C., Olivé, M., ... & Nascimento, A. (2017). C-terminal binding protein 1 (CtBP1) deficiency, mimicking congenital myopathy during infancy. Neuromuscular Disorders, 27, S186.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-CTBP1 Recombinant Antibody (CAP1025)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CTBP1 Recombinant Antibody (4D6)

Mouse Anti-CTBP1 Recombinant Antibody (2G11)

Mouse Anti-CTBP1 Recombinant Antibody (0250)

Rabbit Anti-CTBP1 Recombinant Antibody (CBWJC-3302)

Mouse Anti-CTBP1 Recombinant Antibody (2G7)

Mouse Anti-CTBP1 Recombinant Antibody (0251)

Mouse Anti-CTBP1 Recombinant Antibody (C0288)

Rabbit Anti-CTBP1 Recombinant Antibody (CBWJC-2074)

Mouse Anti-CTBP1 Recombinant Antibody (CBXC-2227)

Mouse Anti-CTBP1 Recombinant Antibody (CBWJC-3303)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: