CTBP1

CTBP1 (C-Terminal Binding Protein 1) is a Protein Coding gene. Diseases associated with CTBP1 include Chromosome 4P Deletion and Colon Adenoma. Among its related pathways are Ectoderm Differentiation and Chronic myeloid leukemia. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is CTBP2.

C-Terminal Binding Protein 1

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Chromatin silencing Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of histone acetylation Source: BHF-UCL
Negative regulation of histone H4 acetylation Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of histone deacetylation Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell cycle Source: BHF-UCL
Viral genome replication Source: ProtInc
White fat cell differentiation Source: UniProtKB

Cytoplasm; Nucleus

Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome (HADDTS):
An autosomal dominant disorder characterized by delayed motor development, intellectual disability, failure to thrive, hypotonia, ataxia, and tooth enamel defects.

The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
ADP-ribosylated; when cells are exposed to brefeldin A.
Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.