CTBP1
CTBP1 (C-Terminal Binding Protein 1) is a Protein Coding gene. Diseases associated with CTBP1 include Chromosome 4P Deletion and Colon Adenoma. Among its related pathways are Ectoderm Differentiation and Chronic myeloid leukemia. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is CTBP2.
Full Name
C-Terminal Binding Protein 1
Function
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
Biological Process
Chromatin silencing Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of histone acetylation Source: BHF-UCL
Negative regulation of histone H4 acetylation Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of histone deacetylation Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell cycle Source: BHF-UCL
Viral genome replication Source: ProtInc
White fat cell differentiation Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of histone acetylation Source: BHF-UCL
Negative regulation of histone H4 acetylation Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of histone deacetylation Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell cycle Source: BHF-UCL
Viral genome replication Source: ProtInc
White fat cell differentiation Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus
Involvement in disease
Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome (HADDTS):
An autosomal dominant disorder characterized by delayed motor development, intellectual disability, failure to thrive, hypotonia, ataxia, and tooth enamel defects.
An autosomal dominant disorder characterized by delayed motor development, intellectual disability, failure to thrive, hypotonia, ataxia, and tooth enamel defects.
PTM
The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
ADP-ribosylated; when cells are exposed to brefeldin A.
Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.
ADP-ribosylated; when cells are exposed to brefeldin A.
Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.
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Anti-CTBP1 antibodies
+ Filters

Target: CTBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CAP1025
Application*: IP, IH, WB
Target: CTBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Cattle
Clone: CBWJC-3303
Application*: WB, IP, IF, E
Target: CTBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-3302
Application*: WB, IF, IP, P
Target: CTBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBWJC-2074
Application*: WB, IF, IP
Target: CTBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-2227
Application*: WB, IP, IF, E, P
Target: CTBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: C5442
Application*: WB, IF, P
Target: CTBP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2G7
Application*: E, WB, P, IF
Target: CTBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G11
Application*: E, WB
Target: CTBP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4D6
Application*: WB, E, IF
Target: CTBP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: C0288
Application*: WB, IP, IF, E, P
Target: CTBP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 0251
Application*: WB, IP, IF, E, P
Target: CTBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 0250
Application*: WB, IP, IF, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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