Rabbit Anti-CXCL13 Recombinant Antibody (C2963) (V2LY-0125-LY660)

Go to compare Compare Online Inquiry
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
C2963
Application
IF, WB, IHC-P
Immunogen
Recombinant protein within human CXCL13/BLC/BCA-1 aa 1-109.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:1,000
IF(ICC)1:400
IHC-P1:100-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA, Glycerol & PBS
Preservative
Sodium Azide
Concentration
1 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
C-X-C Motif Chemokine Ligand 13
Entrez Gene ID
UniProt ID
Function
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
Biological Process
Activation of GTPase activity Source: BHF-UCL
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
B cell chemotaxis Source: BHF-UCL
Cell-cell signaling Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chronic inflammatory response Source: BHF-UCL
Defense response to bacterium Source: BHF-UCL
Endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
Germinal center formation Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: BHF-UCL
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
Negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
Positive regulation of integrin activation Source: BHF-UCL
Positive regulation of T cell chemotaxis Source: BHF-UCL
Regulation of angiogenesis Source: BHF-UCL
Regulation of humoral immune response Source: BHF-UCL
Cellular Location
Secreted

Perreau, M., Suffiotti, M., Marques-Vidal, P., Wiedemann, A., Levy, Y., Laouénan, C., ... & Pantaleo, G. (2021). The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients. Nature Communications, 12(1), 1-10.

Chen, F., Li, X., Li, Z., Zhou, Y., Qiang, Z., & Ma, H. (2020). The roles of chemokine (CXC motif) ligand 13 in spinal cord ischemia-reperfusion injury in rats. Brain Research, 1727, 146489.

Hussain, M., Adah, D., Tariq, M., Lu, Y., Zhang, J., & Liu, J. (2019). CXCL13/CXCR5 signaling axis in cancer. Life sciences, 227, 175-186.

Zhu, L., Zhang, G., Wang, P., Zhang, L., Ji, J., Liu, X., ... & Wang, X. (2019). The effect of CXC motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy. Photodiagnosis and Photodynamic Therapy, 26, 389-394.

Kazanietz, M. G., Durando, M., & Cooke, M. (2019). CXCL13 and its receptor CXCR5 in cancer: inflammation, immune response, and beyond. Frontiers in endocrinology, 10, 471.

Wei, Y., Lin, C., Li, H., Xu, Z., Wang, J., Li, R., ... & Xu, J. (2018). CXCL13 expression is prognostic and predictive for postoperative adjuvant chemotherapy benefit in patients with gastric cancer. Cancer Immunology, Immunotherapy, 67(2), 261-269.

Wagner, J. N., Weis, S., Kubasta, C., Panholzer, J., & von Oertzen, T. J. (2018). CXCL13 as a diagnostic marker of neuroborreliosis and other neuroinflammatory disorders in an unselected group of patients. Journal of Neurology, 265(1), 74-81.

Xu, L., Liang, Z., Li, S., & Ma, J. (2018). Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast cancer. Oncology Letters, 15(6), 9293-9298.

Meng, X., Yu, X., Dong, Q., Xu, X., Li, J., Xu, Q., ... & Zhou, C. (2018). Distribution of circulating follicular helper T cells and expression of interleukin‑21 and chemokine C‑X‑C ligand 13 in gastric cancer. Oncology Letters, 16(3), 3917-3922.

Pietikäinen, A., Oksi, J., & Hytönen, J. (2018). Point-of-care testing for CXCL13 in Lyme neuroborreliosis. Diagnostic Microbiology and Infectious Disease, 91(3), 226-228.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Rabbit Anti-CXCL13 Recombinant Antibody (C2963)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.