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Mouse Anti-CXCL16 Recombinant Antibody (CBCNC-521) (V2LY-0125-LY687)


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Summary

Host Animal
Mouse
Specificity
Human, Pig
Clone
CBCNC-521
Antibody Isotype
IgG1, κ
Application
IF, WB, IHC

Basic Information

Immunogen
Recombinant Human CXCL16 (Asn30-Pro118).
Host Species
Mouse
Specificity
Human, Pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB0.5-2 μg/mL
IF(ICC)5-20 μg/mL
IHC5-20 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Glycerol & PBS
Preservative
Sodium Azide
Concentration
1 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-X-C Motif Chemokine Ligand 16
Entrez Gene ID
58191
UniProt ID
Q9H2A7
Function
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).

Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Biological Process
Chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Positive regulation of cell growth Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Receptor-mediated endocytosis Source: UniProtKB
Response to cytokine Source: BHF-UCL
Response to interferon-gamma Source: BHF-UCL
Response to tumor necrosis factor Source: BHF-UCL
T cell chemotaxis Source: GO_Central
Cellular Location
Cell membrane; Secreted. Also exists as a soluble form.
Topology
Extracellular: 30-205
Helical: 206-226
Cytoplasmic: 227-254
PTM
Glycosylated.
More Infomation

Liu, W., Wang, L., Li, X., Gao, C., Zhou, J., Zhou, J., ... & Yang, J. (2021). CXC Motif Chemokine Ligand 16 Is a Potent Predictor of Outcomes in Dialysis Patients. American Journal of Nephrology, 52(9), 725-734.

Gong, Y., Li, J., Huang, L., Liu, Y., & Cao, J. (2022). Prognostic and pathogenic role of CXC Motif Ligand 16 in sepsis. Microbes and infection, 24(1), 104882.

Shabgah, A. G., Qasim, M. T., Mostafavi, S. M., Zekiy, A. O., Ezzatifar, F., Ahmadi, M., ... & Navashenaq, J. G. (2021). CXC chemokine ligand 16: a Swiss army knife chemokine in cancer. Expert Reviews in Molecular Medicine, 23.

Ma, Z., Ma, C., Zhang, Q., Bai, Y., Mu, K., Liu, X., & Yang, Q. (2021). Role of CXCL16 in BLM-induced epithelial–mesenchymal transition in human A549 cells. Respiratory research, 22(1), 1-10.

Han, J., Fu, R., Chen, C., Cheng, X., Guo, T., Huangfu, L., ... & Ji, J. (2021). CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways. International journal of biological sciences, 17(11), 2841.

Schranz, D., Molnar, T., Erdo-Bonyar, S., Simon, D., Berki, T., Zavori, L., ... & Csecsei, P. (2021). Fatty Acid-Binding Protein 3 and CXC-Chemokine Ligand 16 are Associated with Unfavorable Outcome in Aneurysmal Subarachnoid Hemorrhage. Journal of Stroke and Cerebrovascular Diseases, 30(11), 106068.

Juárez-Rodríguez, P., Godínez-Rubí, M., Guzmán-Brambila, C., Padilla-Velarde, E., Orozco-Barocio, A., Ortuño-Sahagún, D., & Rojas-Mayorquín, A. E. (2020). Prenatal alcohol exposure in rats diminishes postnatal cxcl16 chemokine ligand brain expression. Brain sciences, 10(12), 987.

Andersen, T., Ueland, T., Ghukasyan Lakic, T., Åkerblom, A., Bertilsson, M., Aukrust, P., ... & PLATO Investigators. (2019). CXC ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(11), 2402-2410.

Liang, K., Liu, Y., Eer, D., Liu, J., Yang, F., & Hu, K. (2018). High CXC chemokine ligand 16 (CXCL16) expression promotes proliferation and metastasis of lung cancer via regulating the NF-κB pathway. Medical science monitor: international medical journal of experimental and clinical research, 24, 405.

Lang, K., Bonberg, N., Robens, S., Behrens, T., Hovanec, J., Deix, T., ... & Brüning, T. (2017). Soluble chemokine (CXC motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas. Oncotarget, 8(62), 104946.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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