Mouse Anti-CXCL17 Recombinant Antibody (CBXC-1181) (CBMAB-C1447-CQ)

Name: Mouse Anti-CXCL17 Recombinant Antibody (CBXC-1181)
SKU: CBMAB-C1447-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-1181

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 24-66 mapping within an internal region of human VCC-1.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

More Infomation

Target

Full Name

C-X-C Motif Chemokine Ligand 17

Entrez Gene ID

284340

UniProt ID

Q6UXB2

Function

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081).

Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081).

Acts as an anti-inflammatory in the stomach (PubMed:23115081).

May play a role in the innate defense against infections (PubMed:17307946).

Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).

4-Cys CXCL17:
seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.

Biological Process

Activation of MAPK activity Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Macrophage chemotaxis Source: GO_Central
Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: UniProtKB
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of vascular endothelial growth factor production Source: UniProtKB

Cellular Location

Secreted

PTM

Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.

Wang, L. P., Lin, J., Ma, X. Q., Xu, D. Y., Shi, C. F., Wang, W., & Jiang, X. J. (2021). Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17 axis. Journal of Experimental & Clinical Cancer Research, 40(1), 1-16.

Choreño-Parra, J. A., Jiménez-Álvarez, L. A., Ramírez-Martínez, G., Sandoval-Vega, M., Salinas-Lara, C., Sánchez-Garibay, C., ... & Zúñiga, J. (2021). CXCL17 is a specific diagnostic biomarker for severe pandemic influenza A (H1N1) that predicts poor clinical outcome. Frontiers in immunology, 12.

Fermin, J. M., Alam, M. M., Gu, X., Asarkar, A., Nathan, C. A., & Khandelwal, A. R. (2021). CXCL17 as a prognostic biomarker for aggressive cutaneous squamous cell carcinoma.

Yao, H., Lv, Y., Bai, X., Yu, Z., & Liu, X. (2020). Prognostic value of CXCL17 and CXCR8 expression in patients with colon cancer. Oncology letters, 20(3), 2711-2720.

Choreño-Parra, J. A., Thirunavukkarasu, S., Zúñiga, J., & Khader, S. A. (2020). The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine. Cytokine & growth factor reviews, 53, 53-62.

Liu, W., Xie, X., & Wu, J. (2020). Mechanism of lung adenocarcinoma spine metastasis induced by CXCL17. Cellular Oncology, 43(2), 311-320.

Rojewska, E., Ciapała, K., & Mika, J. (2019). Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model. Pharmacological Reports, 71(1), 139-148.

Khandelwal, A. R., Alam, M. M., Moore-Medlin, T., Savage, H. A., & Nathan, C. A. O. (2019). Role of the CXCL17-CXCR8 (GPR35) axis in cutaneous squamous cell carcinoma.

Zhang, K., Liang, Y., Feng, Y., Wu, W., Zhang, H., He, J., ... & Zhen, G. (2018). Decreased epithelial and sputum miR-221-3p associates with airway eosinophilic inflammation and CXCL17 expression in asthma. American Journal of Physiology-Lung Cellular and Molecular Physiology, 315(2), L253-L264.

Guo, Y. J., Zhou, Y. J., Yang, X. L., Shao, Z. M., & Ou, Z. L. (2017). The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer. Biochemical and biophysical research communications, 493(3), 1159-1167.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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