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CXCL17

CXCL17 (C-X-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CXCL17 include Cholera. Among its related pathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions.

Full Name

C-X-C Motif Chemokine Ligand 17

Function

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081).

Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081).

Acts as an anti-inflammatory in the stomach (PubMed:23115081).

May play a role in the innate defense against infections (PubMed:17307946).

Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).

4-Cys CXCL17:
seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.

Biological Process

Activation of MAPK activity Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Macrophage chemotaxis Source: GO_Central
Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: UniProtKB
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of vascular endothelial growth factor production Source: UniProtKB

Cellular Location

Secreted

PTM

Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.

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Anti-CXCL17 antibodies

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Human Recombinant CXCL17 protein, His Tag (V2LY-0526-LY3435)

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Target: CXCL17

Expressed Host: Yeast

Sequence: Amino Acid: 24-119

Tag: His Tag

Mouse Anti-CXCL17 Recombinant Antibody (C1277) (V2LY-0125-LY690)

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Target: CXCL17

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: C1277

Application*: IH, IF

Rat Anti-CXCL17 Recombinant Antibody (CBYY-1543) (V2LY-0125-LY689)

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Target: CXCL17

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBYY-1543

Application*: WB

Mouse Anti-CXCL17 Recombinant Antibody (CBYY-1542) (V2LY-0125-LY688)

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Target: CXCL17

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-1542

Application*: P, F, IF, WB

Mouse Anti-CXCL17 Recombinant Antibody (CBXC-1181) (CBMAB-C1447-CQ)

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Target: CXCL17

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-1181

Application*: WB, IP, IF, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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