CXCL17

CXCL17 (C-X-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CXCL17 include Cholera. Among its related pathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions.

C-X-C Motif Chemokine Ligand 17

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081).

Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081).

Acts as an anti-inflammatory in the stomach (PubMed:23115081).

May play a role in the innate defense against infections (PubMed:17307946).

Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).

4-Cys CXCL17:
seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.

Activation of MAPK activity Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Macrophage chemotaxis Source: GO_Central
Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: UniProtKB
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of vascular endothelial growth factor production Source: UniProtKB

Secreted

Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.