Human Recombinant CXCL17 protein, His Tag (V2LY-0526-LY3435)

Name: Human Recombinant CXCL17 protein, His Tag
SKU: V2LY-0526-LY3435
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Yeast

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CXCL17 protein, His Tag consist of Amino Acid: 24-119 and predicts a molecular mass of 12.7 kDa.

Molecule Mass

12.7 kDa

Sequence

Amino Acid: 24-119

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-X-C Motif Chemokine Ligand 17

Function

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081).

Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081).

Acts as an anti-inflammatory in the stomach (PubMed:23115081).

May play a role in the innate defense against infections (PubMed:17307946).

Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).

4-Cys CXCL17:
seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.

Biological Process

Activation of MAPK activity Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Macrophage chemotaxis Source: GO_Central
Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: UniProtKB
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of vascular endothelial growth factor production Source: UniProtKB

Cellular Location

Secreted

PTM

Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.

Wang, L. P., Lin, J., Ma, X. Q., Xu, D. Y., Shi, C. F., Wang, W., & Jiang, X. J. (2021). Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17 axis. Journal of Experimental & Clinical Cancer Research, 40(1), 1-16.

Choreño-Parra, J. A., Jiménez-Álvarez, L. A., Ramírez-Martínez, G., Sandoval-Vega, M., Salinas-Lara, C., Sánchez-Garibay, C., ... & Zúñiga, J. (2021). CXCL17 is a specific diagnostic biomarker for severe pandemic influenza A (H1N1) that predicts poor clinical outcome. Frontiers in immunology, 12.

Fermin, J. M., Alam, M. M., Gu, X., Asarkar, A., Nathan, C. A., & Khandelwal, A. R. (2021). CXCL17 as a prognostic biomarker for aggressive cutaneous squamous cell carcinoma.

Yao, H., Lv, Y., Bai, X., Yu, Z., & Liu, X. (2020). Prognostic value of CXCL17 and CXCR8 expression in patients with colon cancer. Oncology letters, 20(3), 2711-2720.

Choreño-Parra, J. A., Thirunavukkarasu, S., Zúñiga, J., & Khader, S. A. (2020). The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine. Cytokine & growth factor reviews, 53, 53-62.

Liu, W., Xie, X., & Wu, J. (2020). Mechanism of lung adenocarcinoma spine metastasis induced by CXCL17. Cellular Oncology, 43(2), 311-320.

Rojewska, E., Ciapała, K., & Mika, J. (2019). Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model. Pharmacological Reports, 71(1), 139-148.

Khandelwal, A. R., Alam, M. M., Moore-Medlin, T., Savage, H. A., & Nathan, C. A. O. (2019). Role of the CXCL17-CXCR8 (GPR35) axis in cutaneous squamous cell carcinoma.

Zhang, K., Liang, Y., Feng, Y., Wu, W., Zhang, H., He, J., ... & Zhen, G. (2018). Decreased epithelial and sputum miR-221-3p associates with airway eosinophilic inflammation and CXCL17 expression in asthma. American Journal of Physiology-Lung Cellular and Molecular Physiology, 315(2), L253-L264.

Guo, Y. J., Zhou, Y. J., Yang, X. L., Shao, Z. M., & Ou, Z. L. (2017). The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer. Biochemical and biophysical research communications, 493(3), 1159-1167.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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