Mouse Anti-CYP2C19 Recombinant Antibody (CBWJC-3552) (V2LY-0125-LY952)

Name: Mouse Anti-CYP2C19 Recombinant Antibody (CBWJC-3552)
SKU: V2LY-0125-LY952
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-3552

Application

WB, IHC

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Cytochrome p450 2C19/CYP2C19.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	0.1-0.5 μg/mL
IHC	0.5-1 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS & Trehalose

Preservative

Sodium Azide

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cytochrome P450 Family 2 Subfamily C Member 19

Entrez Gene ID

1557

UniProt ID

P33261

Function

A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997).

Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768).

Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576).

Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794).

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307).

Biological Process

Drug metabolic process Source: BHF-UCL
Epoxygenase P450 pathway Source: GO_Central
Exogenous drug catabolic process Source: BHF-UCL
Heterocycle metabolic process Source: BHF-UCL
Monoterpenoid metabolic process Source: BHF-UCL
Omega-hydroxylase P450 pathway Source: Reactome
Organic acid metabolic process Source: GO_Central
Steroid metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: GO_Central

Cellular Location

Endoplasmic reticulum membrane; Microsome membrane

Botton, M. R., Whirl‐Carrillo, M., Del Tredici, A. L., Sangkuhl, K., Cavallari, L. H., Agúndez, J. A., ... & Gaedigk, A. (2021). PharmVar GeneFocus: CYP2C19. Clinical Pharmacology & Therapeutics, 109(2), 352-366.

Koopmans, A. B., Braakman, M. H., Vinkers, D. J., Hoek, H. W., & van Harten, P. N. (2021). Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19. Translational psychiatry, 11(1), 1-16.

Wang, Y., Meng, X., Wang, A., Xie, X., Pan, Y., Johnston, S. C., ... & Wang, B. (2021). Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA. New England Journal of Medicine, 385(27), 2520-2530.

Pratt, V. M., Del Tredici, A. L., Hachad, H., Ji, Y., Kalman, L. V., Scott, S. A., & Weck, K. E. (2018). Recommendations for clinical CYP2C19 genotyping allele selection: a report of the association for molecular pathology. The Journal of Molecular Diagnostics, 20(3), 269-276.

Cavallari, L. H., Lee, C. R., Beitelshees, A. L., Cooper-DeHoff, R. M., Duarte, J. D., Voora, D., ... & IGNITE Network. (2018). Multisite investigation of outcomes with implementation of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention. JACC: Cardiovascular Interventions, 11(2), 181-191.

Dean, L. (2018). Clopidogrel therapy and CYP2C19 genotype. Medical Genetics Summaries [Internet].

El Rouby, N., Lima, J. J., & Johnson, J. A. (2018). Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine. Expert opinion on drug metabolism & toxicology, 14(4), 447-460.

Jukić, M. M., Haslemo, T., Molden, E., & Ingelman-Sundberg, M. (2018). Impact of CYP2C19 genotype on escitalopram exposure and therapeutic failure: a retrospective study based on 2,087 patients. American Journal of Psychiatry, 175(5), 463-470.

Empey, P. E., Stevenson, J. M., Tuteja, S., Weitzel, K. W., Angiolillo, D. J., Beitelshees, A. L., ... & IGNITE Network. (2018). Multisite investigation of strategies for the implementation of CYP2C19 genotype‐guided antiplatelet therapy. Clinical Pharmacology & Therapeutics, 104(4), 664-674.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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