Mouse Anti-DCD Recombinant Antibody (D0337) (CBMAB-D0337-YC)

Name: Mouse Anti-DCD Recombinant Antibody (D0337)
SKU: CBMAB-D0337-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

D0337

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 20-110 mapping at the C-terminus of human Dermcidin.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
ELISA	1:100-1:1,000
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

More Infomation

Target

Full Name

Dermcidin

Entrez Gene ID

117159

UniProt ID

P81605

Function

DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).

Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Defense response to bacterium Source: UniProtKB-KW
Defense response to fungus Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Killing by host of symbiont cells Source: CACAO
Killing of cells of other organism Source: UniProtKB

Cellular Location

Secreted

Farshadzadeh, Z., Pourhajibagher, M., Taheri, B., Ekrami, A., Modarressi, M. H., Azimzadeh, M., & Bahador, A. (2022). Antimicrobial and anti-biofilm potencies of dermcidin-derived peptide DCD-1L against Acinetobacter baumannii: an in vivo wound healing model. BMC microbiology, 22(1), 1-13.

Qiu, F., Long, H., Zhang, L., Liu, J., Yang, Z., & Huang, X. (2022). Dermcidin Enhances the Migration, Invasion, and Metastasis of Hepatocellular Carcinoma Cells In Vitro and In Vivo. Journal of Clinical and Translational Hepatology, (000), 0-0.

Lager, T. W., Conner, C., Keating, C. R., Warshaw, J. N., & Panopoulos, A. D. (2021). Cell surface Grp78 and dermcidin cooperate to regulate breast cancer cell migration through Wnt signaling. Oncogene, 40(23), 4050-4059.

Alatas, E. T., Kara Polat, A., Kalayci, M., Dogan, G., & Akin Belli, A. (2019). Plasma dermcidin levels in acne patients, and the effect of isotretinoin treatment on dermcidin levels. Dermatologic Therapy, 32(5), e13044.

Song, C., de Groot, B. L., & Sansom, M. S. (2019). Lipid bilayer composition influences the activity of the antimicrobial peptide dermcidin channel. Biophysical journal, 116(9), 1658-1666.

Qiu, F., Qiu, F., Liu, L., Liu, J., Xu, J., & Huang, X. (2018). The Role of dermcidin in the diagnosis and staging of hepatocellular carcinoma. Genetic Testing and Molecular Biomarkers, 22(4), 218-223.

Mohanraj, U., Kinnunen, O., Kaya, M. E., Aranko, A. S., Viskari, H., & Linder, M. (2018). SUMO-based expression and purification of dermcidin-derived DCD-1L, a human antimicrobial peptide, in Escherichia coli. BioRxiv, 343418.

Nguyen, V. S., Tan, K. W., Ramesh, K., Chew, F. T., & Mok, Y. K. (2017). Structural basis for the bacterial membrane insertion of dermcidin peptide, DCD-1L. Scientific reports, 7(1), 1-11.

Zeth, K., & Sancho-Vaello, E. (2017). The human antimicrobial peptides dermcidin and LL-37 show novel distinct pathways in membrane interactions. Frontiers in chemistry, 5, 86.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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