Mouse Anti-DDX59 Recombinant Antibody (2G1) (CBMAB-D0627-YC)

Name: Mouse Anti-DDX59 Recombinant Antibody (2G1)
SKU: CBMAB-D0627-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2G1

Application

IHC-P, WB

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-303 of human DDX59 (NP_001026895) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-303

More Infomation

Target

Full Name

DEAD-Box Helicase 59

Introduction

DDX59 (DEAD-Box Helicase 59) is a protein coding gene. Diseases associated with DDX59 include Orofaciodigital Syndrome V and Orofaciodigital Syndrome. It has proved that the protein has nucleic acid binding and helicase activity. And a paralog is DDX4.

Entrez Gene ID

83479

UniProt ID

Q5T1V6

Alternative Names

DEAD-Box Helicase 59; Zinc Finger HIT Domain-Containing Protein 5; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 59; DEAD Box Protein 59; ZNHIT5; Probable ATP-Dependent RNA Helicase DDX59; EC 3.6.4.13; EC 3.6.1; OFD5;

Cellular Location

Cytoplasm; Nucleus. Exhibits granular localization in the nucleus, as well as in the cytoplasm.

Involvement in disease

Orofaciodigital syndrome 5 (OFD5):
A form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD5 patients show the core features of cleft palate, lobulated tongue, and polydactyly. Additional features include frontal bossing and intellectual disability.

Hu, K. Q., & Ao, X. S. (2022). Long non-coding RNA DLGAP1 antisense RNA 1 accelerates glioma progression via the microRNA-628-5p/DEAD-box helicase 59 pathway. Clinics, 77.

Salpietro, V., Efthymiou, S., Manole, A., Maurya, B., Wiethoff, S., Ashokkumar, B., ... & Houlden, H. (2018). A loss‐of‐function homozygous mutation in DDX59 implicates a conserved DEAD‐box RNA helicase in nervous system development and function. Human mutation, 39(2), 187-192.

Faily, S., Perveen, R., Urquhart, J., Chandler, K., & Clayton-Smith, J. (2017). Confirmation that mutations in DDX59 cause an autosomal recessive form of oral-facial-digital syndrome: Further delineation of the DDX59 phenotype in two new families. European journal of medical genetics, 60(10), 527-532.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-DDX59 Recombinant Antibody (1F11) (CAT#: CBMAB-D0623-YC)

Mouse Anti-DDX59 Recombinant Antibody (D0623) (CAT#: V2LY-0425-LY116)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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