Mouse Anti-DGKB Recombinant Antibody (1F9) (V2LY-0425-LY243)

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Basic Information

Host Animal
Mouse
Clone
1F9
Application
WB
Immunogen
E. coli-derived recombinant human DGK-beta (Met1-Ser143).
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB0.5 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Trehalose & PBS
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Diacylglycerol Kinase Beta
Entrez Gene ID
UniProt ID
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity).

Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity).

Isoform 2:
Does not associate with membranes but has a diacylglycerol kinase activity.
Biological Process
Diacylglycerol metabolic process Source: UniProtKB
Glycerolipid metabolic process Source: BHF-UCL
Intracellular signal transduction Source: GO_Central
Lipid phosphorylation Source: BHF-UCL
Modulation of chemical synaptic transmission Source: Ensembl
Phosphatidic acid biosynthetic process Source: UniProtKB
Platelet activation Source: Reactome
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Regulation of postsynapse organization Source: Ensembl
Response to bacterium Source: Ensembl
Cellular Location
Postsynaptic cell membrane; Cell membrane; Cytoplasm. Translocation to the plasma membrane is induced by phorbol esters.
Isoform 2: Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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