Human Recombinant DGKB , Active protein, His Tag (V2LY-0526-LY3558)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant DGKB , Active protein, His Tag consist of Amino Acid: 11-end and predicts a molecular mass of 92 kDa.
Molecule Mass
92 kDa
Sequence
Amino Acid: 11-end
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
PBS
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
Diacylglycerol Kinase Beta
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity).

Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity).

Isoform 2:
Does not associate with membranes but has a diacylglycerol kinase activity.
Biological Process
Diacylglycerol metabolic process Source: UniProtKB
Glycerolipid metabolic process Source: BHF-UCL
Intracellular signal transduction Source: GO_Central
Lipid phosphorylation Source: BHF-UCL
Modulation of chemical synaptic transmission Source: Ensembl
Phosphatidic acid biosynthetic process Source: UniProtKB
Platelet activation Source: Reactome
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Regulation of postsynapse organization Source: Ensembl
Response to bacterium Source: Ensembl
Cellular Location
Postsynaptic cell membrane; Cell membrane; Cytoplasm. Translocation to the plasma membrane is induced by phorbol esters.
Isoform 2: Cytoplasm
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For research use only. Not intended for any clinical use.

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