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Mouse Anti-DGKG Recombinant Antibody (CBYCD-254) (CBMAB-D0789-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Diacylglycerol Kinase Gamma (DGKG). The antibody can be used for immunoassay techniques, such as WB.
See all DGKG antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYCD-254
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human DGK-gamma, Gly2-Ser126, Accession # P49619
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Diacylglycerol Kinase Gamma
Introduction
DGKG is an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells.
Entrez Gene ID
Human1608
Mouse110197
Rat25666
UniProt ID
HumanP49619
MouseQ91WG7
RatP49620
Alternative Names
Diacylglycerol Kinase Gamma; Diacylglycerol Kinase, Gamma 90kDa; Diglyceride Kinase Gamma; DAG Kinase Gamma; EC 2.7.1.107; DGK-GAMMA; DAGK3; Diacylglycerol Kinase, Gamma (90kD); Diacylglyerol Kinase Gamma;
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity).

Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597).

Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity).
Biological Process
Diacylglycerol metabolic process Source: UniProtKB
Glycerolipid metabolic process Source: BHF-UCL
Intracellular signal transduction Source: GO_Central
Lipid phosphorylation Source: UniProtKB
Negative regulation of protein kinase C signaling Source: UniProtKB
Neuron development Source: Ensembl
Phosphatidic acid biosynthetic process Source: UniProtKB
Platelet activation Source: Reactome
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Regulation of dendrite development Source: Ensembl
Cellular Location
Cytosol; Cytoskeleton; Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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