Human Recombinant DGKG, Active protein, His Tag-1 (V2LY-0526-LY3566)

Name: Human Recombinant DGKG, Active protein, His Tag-1
SKU: V2LY-0526-LY3566
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant DGKG, Active protein, His Tag consist of Amino Acid: Full Length and predicts a molecular mass of 90 kDa.

Molecule Mass

90 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Diacylglycerol Kinase Gamma

Function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity).

Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597).

Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity).

Biological Process

Diacylglycerol metabolic process Source: UniProtKB
Glycerolipid metabolic process Source: BHF-UCL
Intracellular signal transduction Source: GO_Central
Lipid phosphorylation Source: UniProtKB
Negative regulation of protein kinase C signaling Source: UniProtKB
Neuron development Source: Ensembl
Phosphatidic acid biosynthetic process Source: UniProtKB
Platelet activation Source: Reactome
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Regulation of dendrite development Source: Ensembl

Cellular Location

Cytosol; Cytoskeleton; Membrane

Hattori, Y., Yamasaki, T., Ohashi, T., Miyanohana, Y., Kusumoto, T., Maeda, R., ... & Koike, T. (2021). Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain. Journal of Medicinal Chemistry, 64(16), 11990-12002.

Trinh, I., Gluscencova, O. B., & Boulianne, G. L. (2019). An in vivo screen for neuronal genes involved in obesity identifies Diacylglycerol kinase as a regulator of insulin secretion. Molecular metabolism, 19, 13-23.

Kai, M., Yamamoto, E., Sato, A., Yamano, H. O., Niinuma, T., Kitajima, H., ... & Suzuki, H. (2017). Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer. Molecular Carcinogenesis, 56(7), 1743-1752.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant DGKG, Active protein, GST Tag (CAT#: V2LY-0526-LY3563)

Human Recombinant DGKG, Active protein, GST Tag-1 (CAT#: V2LY-0526-LY3564)

Human Recombinant DGKG, Active protein, His Tag (CAT#: V2LY-0526-LY3565)

Human Recombinant DGKG , Active protein, His Tag (CAT#: V2LY-0526-LY3567)

Related Products

Human Recombinant DGKG , Active protein, His Tag (CAT#: V2LY-0526-LY3567)

Human Recombinant DGKG, Active protein, GST Tag-1 (CAT#: V2LY-0526-LY3564)

Human Recombinant DGKG, Active protein, His Tag (CAT#: V2LY-0526-LY3565)

Human Recombinant DGKG, Active protein, GST Tag (CAT#: V2LY-0526-LY3563)

Mouse Anti-DGKG Recombinant Antibody (CBYCD-254) (CAT#: V2LY-0425-LY248)

Mouse Anti-DGKG Recombinant Antibody (CBYCD-254) (CAT#: CBMAB-D0789-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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