Mouse Anti-DHFR2 Recombinant Antibody (1E2) (CBMAB-D0826-YC)

Name: Mouse Anti-DHFR2 Recombinant Antibody (1E2)
SKU: CBMAB-D0826-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E2

Application

WB, ICC, IF

Immunogen

Human recombinant protein fragment corresponding to amino acids 4-185 of human DHFRL1(NP_789785) produced in E.coli

Specificity

Human, Mouse, Dog

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Dihydrofolate Reductase 2

Introduction

DHFR2 (Dihydrofolate Reductase 2) is a protein coding gene. Among its related pathways are One carbon pool by folate and Metabolism. And a paralog is DHFR.

Entrez Gene ID

Human	200895
Mouse	111208

UniProt ID

Human

Q86XF0

Alternative Names

Dihydrofolate Reductase 2; Dihydrofolate Reductase, Mitochondrial; Dihydrofolate Reductase-Like Protein 1; Dihydrofolate Reductase Pseudogene 4; Dihydrofolate Reductase Like 1; EC 1.5.1.3;

Function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.

Biological Process

Dihydrofolate metabolic process Source: GO_Central
Folic acid metabolic process Source: GO_Central
Glycine biosynthetic process Source: InterPro
One-carbon metabolic process Source: UniProtKB-KW
Tetrahydrofolate biosynthetic process Source: GO_Central
Tetrahydrofolate metabolic process Source: UniProtKB
Thymidine biosynthetic process Source: UniProtKB

Cellular Location

Mitochondrion; Mitochondrion matrix; Mitochondrion inner membrane

Pangilinan, F., Finlay, E. K., Molloy, A. M., Abaan, H. O., Shane, B., Mills, J. L., ... & Parle-McDermott, A. (2021). A dihydrofolate reductase 2 (DHFR2) variant is associated with risk of neural tube defects in an Irish cohort but not in a United Kingdom cohort. American journal of medical genetics. Part A, 185(4), 1307-1311.

Kabir, E. R., Siam, M. K. S., Mustafa, N., & Kabir, S. M. (2018, December). Molecular docking reveals pitavastatin and related molecules antagonize 1DHF and its pseudogene DHFR2 in cancer treatment. In Proceedings of the 9th International Conference on Computational Systems-Biology and Bioinformatics (pp. 1-9).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DHFR2 Recombinant Antibody (1E2) (CAT#: V2LY-0425-LY273)

Related Products

Mouse Anti-DHFR2 Recombinant Antibody (1E2) (CAT#: V2LY-0425-LY273)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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