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DHFR2

DHFR2 (Dihydrofolate Reductase 2) is a Protein Coding gene. Among its related pathways are One carbon pool by folate and Metabolism. An important paralog of this gene is DHFR.

Full Name

Dihydrofolate Reductase 2

Function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.

Biological Process

Dihydrofolate metabolic process Source: GO_Central
Folic acid metabolic process Source: GO_Central
Glycine biosynthetic process Source: InterPro
One-carbon metabolic process Source: UniProtKB-KW
Tetrahydrofolate biosynthetic process Source: GO_Central
Tetrahydrofolate metabolic process Source: UniProtKB
Thymidine biosynthetic process Source: UniProtKB

Cellular Location

Mitochondrion; Mitochondrion matrix; Mitochondrion inner membrane

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Anti-DHFR2 antibodies

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Mouse Anti-DHFR2 Recombinant Antibody (1E2) (CBMAB-D0826-YC)

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Target: DHFR2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Dog

Clone: 1E2

Application*: WB, IC, IF

Mouse Anti-DHFR2 Recombinant Antibody (1E2) (V2LY-0425-LY273)

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Target: DHFR2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Dog, Monkey

Clone: 1E2

Application*: WB, IF

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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