DHFR2

DHFR2 (Dihydrofolate Reductase 2) is a Protein Coding gene. Among its related pathways are One carbon pool by folate and Metabolism. An important paralog of this gene is DHFR.

Full Name

Dihydrofolate Reductase 2

Function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.

Biological Process

Dihydrofolate metabolic process Source: GO_Central
Folic acid metabolic process Source: GO_Central
Glycine biosynthetic process Source: InterPro
One-carbon metabolic process Source: UniProtKB-KW
Tetrahydrofolate biosynthetic process Source: GO_Central
Tetrahydrofolate metabolic process Source: UniProtKB
Thymidine biosynthetic process Source: UniProtKB

Cellular Location

Mitochondrion; Mitochondrion matrix; Mitochondrion inner membrane

Anti-DHFR2 antibodies

Mouse Anti-DHFR2 Recombinant Antibody (1E2) (CBMAB-D0826-YC)

Datasheet

SDS

Target: DHFR2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Dog

Clone: 1E2

Application*: WB, IC, IF

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)