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Mouse Anti-DHX38 Recombinant Antibody (8C117) (CBMAB-D0856-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DEAH-Box Helicase 38 (DHX38). The antibody can be used for immunoassay techniques, such as FC, IIHC-Fr, IP, WB.
See all DHX38 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
8C117
Antibody Isotype
IgG
Application
FC, IIHC-Fr, IP, WB

Basic Information

Immunogen
Partial sequence of recombinant full-length protein to human DHX38
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 38
Introduction
DHX38 is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
Entrez Gene ID
Human9785
Mouse64340
Rat292007
UniProt ID
HumanQ92620
MouseQ80X98
RatD4A321
Alternative Names
DEAH-Box Helicase 38; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 38; DEAH (Asp-Glu-Ala-His) Box Polypeptide 38; ATP-Dependent RNA Helicase DHX38; DEAH Box Protein 38; DDX38; PRP16;
Function
Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131).
Biological Process
mRNA splicing, via spliceosome Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Retinitis pigmentosa 84 (RP84):
A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP84 is an autosomal recessive, early onset form characterized by night blindness by age 4 and complete blindness by age 8. Funduscopy shows severely attenuated retinal vessels, severe macular atrophy, and prominent and deep macular colobomas lacking neuroretinal tissue.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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