Mouse Anti-DHX38 Recombinant Antibody (8C117) (V2LY-0425-LY293)

Name: Mouse Anti-DHX38 Recombinant Antibody (8C117)
SKU: V2LY-0425-LY293
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8C117

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 282-510 mapping within an internal region of human DDX38.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

DEAH (Asp-Glu-Ala-His) box polypeptide 38

Entrez Gene ID

Human	9785
Mouse	64340
Rat	292007

UniProt ID

Human	Q92620
Mouse	Q80X98
Rat	D4A321

Function

Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131).

Biological Process

mRNA splicing, via spliceosome Source: UniProtKB

Cellular Location

Nucleus

Involvement in disease

Retinitis pigmentosa 84 (RP84):
A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP84 is an autosomal recessive, early onset form characterized by night blindness by age 4 and complete blindness by age 8. Funduscopy shows severely attenuated retinal vessels, severe macular atrophy, and prominent and deep macular colobomas lacking neuroretinal tissue.

Obuća, M., Cvačková, Z., Kubovčiak, J., Kolář, M., & Staněk, D. (2022). Retinitis pigmentosa-linked mutation in DHX38 modulates its splicing activity. Plos one, 17(4), e0265742.

Cona, B., Hayashi, T., Yamada, A., Shimizu, N., Yokota, N., Nakato, R., ... & Akiyama, T. (2022). The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen. FEBS Open bio, 12(3), 582-593.

Latif, Z., Chakchouk, I., Schrauwen, I., Lee, K., Santos-Cortez, R. L. P., Abbe, I., ... & Leal, S. M. (2018). Confirmation of the role of DHX38 in the etiology of early-onset retinitis pigmentosa. Investigative Ophthalmology & Visual Science, 59(11), 4552-4557.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DHX38 Recombinant Antibody (8C117) (CAT#: CBMAB-D0856-YC)

Related Products

Mouse Anti-DHX38 Recombinant Antibody (3B9) (CAT#: CBMAB-D0855-YC)

Mouse Anti-DHX38 Recombinant Antibody (3B9) (CAT#: V2LY-0425-LY292)

Mouse Anti-DHX38 Recombinant Antibody (8C117) (CAT#: CBMAB-D0856-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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