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Rabbit Anti-DHX58 Recombinant Antibody (CBYJL-149) (CBMAB-L0220-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJL-149
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DExH-Box Helicase 58
Introduction
Diseases associated with DHX58 include Measles. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include helicase activity and nucleic acid binding. An important paralog of this gene is IFIH1.
Entrez Gene ID
79132
UniProt ID
Q96C10
Alternative Names
DExH-Box Helicase 58; DEXH (Asp-Glu-X-His) Box Polypeptide 58; Probable ATP-Dependent Helicase LGP2; RIG-I-Like Receptor LGP2; Protein D11Lgp2 Homolog; RIG-I-Like Receptor 3; RNA Helicase LGP2; D11lgp2e
Function
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes (PubMed:31256877).

Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
Biological Process
Defense response to virus Source: UniProtKB-KW
Innate immune response Source: GO_Central
Negative regulation of innate immune response Source: UniProtKB
Negative regulation of MDA-5 signaling pathway Source: UniProtKB
Negative regulation of RIG-I signaling pathway Source: UniProtKB
Negative regulation of type I interferon production Source: UniProtKB
Positive regulation of interferon-beta production Source: GO_Central
Positive regulation of MDA-5 signaling pathway Source: UniProtKB
Positive regulation of RIG-I signaling pathway Source: UniProtKB
Positive regulation of type I interferon production Source: UniProtKB
Regulation of innate immune response Source: UniProtKB
Response to bacterium Source: Ensembl
Response to virus Source: UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

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