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Mouse Anti-DLX1 Recombinant Antibody (10B2726) (CBMAB-D1120-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Distal-Less Homeobox 1 (DLX1). The antibody can be used for immunoassay techniques, such as ELISA, ICC, WB.
See all DLX1 antibodies
Published Data
Fig.1 Fold-change of DLX1 and DLX2 expression in RS4.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
10B2726
Antibody Isotype
IgG2a
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 152-256

Target

Full Name
Distal-Less Homeobox 1
Introduction
DLX1 belongs to a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2.
Entrez Gene ID
1745
UniProt ID
P56177
Alternative Names
Distal-Less Homeobox 1; Distal-Less Homeo Box 1;
Function
Plays a role as a transcriptional activator or repressor (PubMed:14671321).

Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321).

Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity).

Likely to play a regulatory role in the development of the ventral forebrain (By similarity).

May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).
Biological Process
Cell differentiation Source: GO_Central
Cellular response to BMP stimulus Source: UniProtKB
Cellular response to transforming growth factor beta stimulus Source: UniProtKB
Cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
Embryonic skeletal system development Source: Ensembl
Forebrain neuron differentiation Source: Ensembl
Hippocampus development Source: Ensembl
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of cellular response to transforming growth factor beta stimulus Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of photoreceptor cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of amacrine cell differentiation Source: UniProtKB
Positive regulation of cell differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Subpallium development Source: Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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