DLX1

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Full Name

Distal-Less Homeobox 1

Function

Plays a role as a transcriptional activator or repressor (PubMed:14671321).

Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321).

Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity).

Likely to play a regulatory role in the development of the ventral forebrain (By similarity).

May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).

Biological Process

Cell differentiation Source: GO_Central
Cellular response to BMP stimulus Source: UniProtKB
Cellular response to transforming growth factor beta stimulus Source: UniProtKB
Cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
Embryonic skeletal system development Source: Ensembl
Forebrain neuron differentiation Source: Ensembl
Hippocampus development Source: Ensembl
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of cellular response to transforming growth factor beta stimulus Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of photoreceptor cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of amacrine cell differentiation Source: UniProtKB
Positive regulation of cell differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Subpallium development Source: Ensembl

Cellular Location

Nucleus