Mouse Anti-DLX1 Recombinant Antibody (3F9) (CBMAB-D1116-YC)

Name: Mouse Anti-DLX1 Recombinant Antibody (3F9)
SKU: CBMAB-D1116-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3F9

Application

ELISA, IF, IP, WB

Immunogen

DLX1 (NP_835221, 152 a.a. ~ 255 a.a) partial recombinant protein with GST tag. The immunogen sequence: YLALPERAEL AASLGLTQTQ VKIWFQNKRS KFKKLMKQGG AALEGSALAN GRALSAGSPP VPPGWNPNSS SGKGSGGNAG SYIPSYTSWY PSAHQEAMQQ PQLM

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 152-255

More Infomation

Target

Full Name

Distal-Less Homeobox 1

Introduction

DLX1 belongs to a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2.

Entrez Gene ID

1745

UniProt ID

P56177

Alternative Names

Distal-Less Homeobox 1; Distal-Less Homeo Box 1;

Function

Plays a role as a transcriptional activator or repressor (PubMed:14671321).

Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321).

Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity).

Likely to play a regulatory role in the development of the ventral forebrain (By similarity).

May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity).

Biological Process

Cell differentiation Source: GO_Central
Cellular response to BMP stimulus Source: UniProtKB
Cellular response to transforming growth factor beta stimulus Source: UniProtKB
Cerebral cortex GABAergic interneuron fate commitment Source: Ensembl
Embryonic skeletal system development Source: Ensembl
Forebrain neuron differentiation Source: Ensembl
Hippocampus development Source: Ensembl
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of cellular response to transforming growth factor beta stimulus Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of oligodendrocyte differentiation Source: Ensembl
Negative regulation of photoreceptor cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of amacrine cell differentiation Source: UniProtKB
Positive regulation of cell differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Subpallium development Source: Ensembl

Cellular Location

Nucleus

Goel, S., Bhatia, V., Kundu, S., Biswas, T., Carskadon, S., Gupta, N., ... & Ateeq, B. (2021). Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression. Nature communications, 12(1), 1-22.

Wang, J., Xie, S., Liu, J., Li, T., Wang, W., & Xie, Z. (2021). MicroRNA-4429 suppresses proliferation of prostate cancer cells by targeting distal-less homeobox 1 and inactivating the Wnt/β-catenin pathway. BMC urology, 21(1), 1-10.

Vanyai, H. K., Garnham, A., May, R. E., McRae, H. M., Collin, C., Wilcox, S., ... & Voss, A. K. (2019). MOZ directs the distal-less homeobox gene expression program during craniofacial development. Development, 146(14), dev175042.

Liu, S., Liu, L. H., Hu, W. W., & Wang, M. (2019). Long noncoding RNA TUG1 regulates the development of oral squamous cell carcinoma through sponging miR‐524‐5p to mediate DLX1 expression as a competitive endogenous RNA. Journal of Cellular Physiology, 234(11), 20206-20216.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DLX1 Recombinant Antibody (3F9) (CAT#: V2LY-0425-LY505)

Antibody Pairs

DLX1 Matched Antibody Pair (341) (CAT#: APMAB-341LY)

Related Products

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Mouse Anti-DLX1 Recombinant Antibody (4H7) (CAT#: V2LY-0425-LY507)

Mouse Anti-DLX1 Recombinant Antibody (3F9) (CAT#: V2LY-0425-LY505)

Mouse Anti-DLX1 Recombinant Antibody (4B7) (CAT#: CBMAB-D1118-YC)

Mouse Anti-DLX1 Monoclonal Antibody (1D11) (CAT#: CBMAB-1029-YC)

DLX1 Matched Antibody Pair (341) (CAT#: APMAB-341LY)

Mouse Anti-DLX1 Recombinant Antibody (4H7) (CAT#: CBMAB-D1119-YC)

Mouse Anti-DLX1 Recombinant Antibody (10B2726) (CAT#: CBMAB-D1120-YC)

Mouse Anti-DLX1 Recombinant Antibody (D1120) (CAT#: V2LY-0425-LY508)

Mouse Anti-DLX1 Recombinant Antibody (1029) (CAT#: V2LY-0425-LY504)

Isotype control

For research use only. Not intended for any clinical use.

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