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Mouse Anti-DMTF1 Antibody (1A8) (CBMAB-0296-YC)

Provided herein are mouse monoclonal antibodies against Human DMTF1. The antibody clone 1A8 can be used for immunoassay techniques, such as IP and MA.
See all DMTF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A8
Antibody Isotype
IgG2a
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DMTF1
Introduction
DMTF1 (cyclin D binding myb-like transcription factors 1) is a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. DMTF1 is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. Also, it activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation.
Entrez Gene ID
9988
UniProt ID
Q9Y222
Alternative Names
DMP1; DMTF; hDMP1
Function
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity).

Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity).

Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
Biological Process
Cell cycle Source: UniProtKB-KW
Regulation of transcription, DNA-templated Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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