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Mouse Anti-DMTF1 Recombinant Antibody (CBYY-C2379) (CBMAB-C3817-YY)

This product is mouse antibody that recognizes DMTF1. The antibody CBYY-C2379 can be used for immunoassay techniques such as: WB
See all DMTF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2379
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Partial sequence of recombinant full-length protein to human Cyclin D Binding myb-Like Transcription Factor 1 (BC070064)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Buffer
0.1 mg/mL
Preservative
PBS, pH 7.4, 1% BSA
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DMTF1
Entrez Gene ID
9988
UniProt ID
Q9Y222
Alternative Names
DAN Domain BMP Antagonist Family Member 5; Cysteine Knot Superfamily 1, BMP Antagonist 3; DAN Domain Family Member 5, BMP Antagonist; Cerberus-Like Protein 2; Gremlin-3; CKTSF1B3; Cerl-2; GREM3; CER2; SP1;
Function
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity).

Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity).

Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
Biological Process
Cell cycle Source: UniProtKB-KW
Regulation of transcription, DNA-templated Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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