Mouse Anti-DNAJC27 Recombinant Antibody (3C1) (V2LY-0425-LY654)

Name: Mouse Anti-DNAJC27 Recombinant Antibody (3C1)
SKU: V2LY-0425-LY654
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

3C1

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

Full-length recombinant DNAJC27.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

DnaJ (Hsp40) homolog, subfamily C, member 27

Entrez Gene ID

51277

UniProt ID

Q9NZQ0

Function

GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.

Biological Process

Intracellular protein transport Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Regulation of MAPK export from nucleus Source: Ensembl

Cellular Location

Nucleus

More Infomation

References

Hammad, M. M., Abu-Farha, M., Hebbar, P., Cherian, P., Al Khairi, I., Melhem, M., ... & Abubaker, J. (2020). MC4R variant rs17782313 associates with increased levels of DNAJC27, ghrelin, and visfatin and correlates with obesity and hypertension in a Kuwaiti cohort. Frontiers in Endocrinology, 11, 437.

Cherian, P. T., Al-Khairi, I., Sriraman, D., Al-Enezi, A., Al-Sultan, D., AlOtaibi, M., ... & Abu-Farha, M. (2018). Increased circulation and adipose tissue levels of DNAJC27/RBJ in obesity and type 2-diabetes. Frontiers in endocrinology, 9, 423.

Al Khairi, I., Sriraman, D., Cherian, P., Tuomilehto, J., Abubaker, J., & Abu-Farha, M. (2017). DnaJ Heat Shock Protein Family (Hsp40) Member C27 (DNAJC27) is a Heat Shock 40 protein (HSP40) family member that is increased the in obese people.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DNAJC27 Recombinant Antibody (3C1)

Related Products

Mouse Anti-DNAJC27 Recombinant Antibody (3C1)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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