Mouse Anti-DOC2A Recombinant Antibody (3C11) (V2LY-0425-LY762)

Name: Mouse Anti-DOC2A Recombinant Antibody (3C11)
SKU: V2LY-0425-LY762
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

3C11

Antibody Isotype

IgG2b, κ

Application

ELISA

Basic Information

Immunogen

Full length recombinant human DOC2A.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

double C2-like domains, alpha

Entrez Gene ID

8448

UniProt ID

Q14183

Function

Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.

Biological Process

Chemical synaptic transmission Source: ProtInc
Nervous system development Source: ProtInc
Regulation of calcium ion-dependent exocytosis Source: UniProtKB
Spontaneous neurotransmitter secretion Source: Ensembl
Synaptic vesicle exocytosis Source: Ensembl

Cellular Location

Lysosome; Synaptic vesicle membrane; Synaptosome

More Infomation

References

Sahid, M. N., Liu, S., Kiyoi, T., Maeyama, K., & Mogi, M. (2021). Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction. Biological and Pharmaceutical Bulletin, 44(12), 1902-1906.

Hu, X., Tang, J., Lan, X., & Mi, X. (2019). Increased expression of DOC2A in human and rat temporal lobe epilepsy. Epilepsy Research, 151, 78-84.

Sahid, M. N., Liu, S., Kiyoi, T., & Maeyama, K. (2018). Zoledronate and clodronate inhibited RBL-2H3 cells degranulation without disturbing Rab27a-Doc2a interaction. In Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) (pp. PO3-4). Japanese Pharmacological Society.

McCammon, J. M., Blaker-Lee, A., Chen, X., & Sive, H. (2017). The 16p11. 2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human molecular genetics, 26(19), 3699-3712.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DOC2A Recombinant Antibody (3C11)

Related Products

Mouse Anti-DOC2A Recombinant Antibody (3C11)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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