DOC2A

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. [provided by RefSeq]

Full Name

double C2-like domains, alpha

Function

Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.

Biological Process

Chemical synaptic transmission Source: ProtInc
Nervous system development Source: ProtInc
Regulation of calcium ion-dependent exocytosis Source: UniProtKB
Spontaneous neurotransmitter secretion Source: Ensembl
Synaptic vesicle exocytosis Source: Ensembl

Cellular Location

Lysosome; Synaptic vesicle membrane; Synaptosome