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Rat Anti-DPP3 Recombinant Antibody (D1571) (V2LY-0425-LY836)

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Summary

Host Animal
Rat
Specificity
Human
Clone
D1571
Antibody Isotype
IgG2a
Application
N, WB

Basic Information

Immunogen
E. coli-derived recombinant human DPP3 protein (aa2-737).
Host Species
Rat
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium Azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
dipeptidyl-peptidase 3
Entrez Gene ID
UniProt ID
Function
Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063).

Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).
Biological Process
Proteolysis Source: UniProtKB
Cellular Location
Cytosol
More Infomation

Malovan, G., Hierzberger, B., Suraci, S., Schaefer, M., Santos, K., Jha, S., & Macheroux, P. (2022). The emerging role of dipeptidyl peptidase 3 in pathophysiology. The FEBS Journal.

Podversnik, H., Jha, S., Macheroux, P., & Breinbauer, R. (2022). Design and synthesis of efficient fluororethylene-peptidomimetic inhibitors of dipeptidyl peptidase III (DPP3). Bioorganic & Medicinal Chemistry, 116831.

Van Lier, D., Kox, M., & Pickkers, P. (2021). Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3. Journal of Internal Medicine, 289(6), 792-806.

Blet, A., Deniau, B., Santos, K., van Lier, D., Azibani, F., Wittebole, X., ... & Mebazaa, A. (2021). Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study. Critical Care, 25(1), 1-10.

Boorsma, E. M., Ter Maaten, J. M., Damman, K., van Veldhuisen, D. J., Dickstein, K., Anker, S. D., ... & Voors, A. A. (2021). Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure. European journal of heart failure, 23(6), 947-953.

Picod, A., Deniau, B., Vaittinada Ayar, P., Genest, M., Julian, N., Azibani, F., & Mebazaa, A. (2021). Alteration of the Renin–Angiotensin–Aldosterone System in Shock: Role of the Dipeptidyl Peptidase 3. American Journal of Respiratory and Critical Care Medicine, 203(4), 526-527.

Ren, X., Yu, J., Guo, L., & Ma, H. (2021). Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling. International Immunopharmacology, 96, 107595.

Jha, S., Taschler, U., Domenig, O., Poglitsch, M., Bourgeois, B., Pollheimer, M., ... & Macheroux, P. (2020). Dipeptidyl peptidase 3 modulates the renin–angiotensin system in mice. Journal of Biological Chemistry, 295(40), 13711-13723.

Rehfeld, L., Funk, E., Jha, S., Macheroux, P., Melander, O., & Bergmann, A. (2019). Novel methods for the quantification of dipeptidyl peptidase 3 (DPP3) concentration and activity in human blood samples. The Journal of Applied Laboratory Medicine, 3(6), 943-953.

Menale, C., Robinson, L. J., Palagano, E., Rigoni, R., Erreni, M., Almarza, A. J., ... & Sobacchi, C. (2019). Absence of dipeptidyl peptidase 3 increases oxidative stress and causes bone loss. Journal of Bone and Mineral Research, 34(11), 2133-2148.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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