Human Recombinant DPP3 protein, His Tag (V2LY-0526-LY3630)

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Basic Information

Expressed Host
E. coli
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant DPP3 protein, His Tag consist of Amino Acid: 2-737 and predicts a molecular mass of 83.6 kDa.
Molecule Mass
83.6 kDa
Verified
HPLC
Sequence
Amino Acid: 2-737
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
dipeptidyl-peptidase 3
Function
Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063).

Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).
Biological Process
Proteolysis Source: UniProtKB
Cellular Location
Cytosol

Malovan, G., Hierzberger, B., Suraci, S., Schaefer, M., Santos, K., Jha, S., & Macheroux, P. (2022). The emerging role of dipeptidyl peptidase 3 in pathophysiology. The FEBS Journal.

Podversnik, H., Jha, S., Macheroux, P., & Breinbauer, R. (2022). Design and synthesis of efficient fluororethylene-peptidomimetic inhibitors of dipeptidyl peptidase III (DPP3). Bioorganic & Medicinal Chemistry, 116831.

Van Lier, D., Kox, M., & Pickkers, P. (2021). Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3. Journal of Internal Medicine, 289(6), 792-806.

Blet, A., Deniau, B., Santos, K., van Lier, D., Azibani, F., Wittebole, X., ... & Mebazaa, A. (2021). Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study. Critical Care, 25(1), 1-10.

Boorsma, E. M., Ter Maaten, J. M., Damman, K., van Veldhuisen, D. J., Dickstein, K., Anker, S. D., ... & Voors, A. A. (2021). Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure. European journal of heart failure, 23(6), 947-953.

Picod, A., Deniau, B., Vaittinada Ayar, P., Genest, M., Julian, N., Azibani, F., & Mebazaa, A. (2021). Alteration of the Renin–Angiotensin–Aldosterone System in Shock: Role of the Dipeptidyl Peptidase 3. American Journal of Respiratory and Critical Care Medicine, 203(4), 526-527.

Ren, X., Yu, J., Guo, L., & Ma, H. (2021). Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling. International Immunopharmacology, 96, 107595.

Jha, S., Taschler, U., Domenig, O., Poglitsch, M., Bourgeois, B., Pollheimer, M., ... & Macheroux, P. (2020). Dipeptidyl peptidase 3 modulates the renin–angiotensin system in mice. Journal of Biological Chemistry, 295(40), 13711-13723.

Rehfeld, L., Funk, E., Jha, S., Macheroux, P., Melander, O., & Bergmann, A. (2019). Novel methods for the quantification of dipeptidyl peptidase 3 (DPP3) concentration and activity in human blood samples. The Journal of Applied Laboratory Medicine, 3(6), 943-953.

Menale, C., Robinson, L. J., Palagano, E., Rigoni, R., Erreni, M., Almarza, A. J., ... & Sobacchi, C. (2019). Absence of dipeptidyl peptidase 3 increases oxidative stress and causes bone loss. Journal of Bone and Mineral Research, 34(11), 2133-2148.

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For research use only. Not intended for any clinical use.

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