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Mouse Anti-DPT Recombinant Antibody (2A11) (CBMAB-D1638-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dermatopontin (DPT). The antibody can be used for immunoassay techniques, such as ELISA.
See all DPT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A11
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dermatopontin
Introduction
DPT is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. DPT is found in various tissues and many of its tyrosine residues are sulphated. DPT is postulated to modify the behavior of TGF-beta through interaction with decorin.
Entrez Gene ID
1805
UniProt ID
Q07507
Alternative Names
Dermatopontin; Tyrosine-Rich Acidic Matrix Protein; TRAMP;
Function
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
Biological Process
Cell adhesion Source: UniProtKB-KW
Collagen fibril organization Source: GO_Central
Negative regulation of cell population proliferation Source: Ensembl
Cellular Location
Extracellular matrix
PTM
Sulfated on tyrosine residue(s).

Jensen, M. M., Bonna, A., Frederiksen, S. J., Hamaia, S. W., Højrup, P., Farndale, R. W., & Karring, H. (2022). Tyrosine-sulfated dermatopontin shares multiple binding sites and recognition determinants on triple-helical collagens with proteins implicated in cell adhesion and collagen folding, fibrillogenesis, cross-linking, and degradation. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1870(5), 140771.

Huang, H., Hao, Z., Long, L., Yin, Z., Wu, C., Zhou, X., & Zhang, B. (2021). Dermatopontin as a potential pathogenic factor in endometrial cancer. Oncology Letters, 21(5), 1-8.

Kramer, A. C., Astuti, Y., Elfstrum, A., Lehrke, M. J., Tolar, J., Blazar, B. R., ... & Lund, T. C. (2021). An irradiated marrow niche reveals a small noncollagenous protein mediator of homing, dermatopontin. Blood Advances, 5(18), 3609-3622.

Sadr-Nabavi, A., Bouromand-Noughabi, S., Tayebi-Meybodi, N., Dadkhah, K., Amini, N., Meindl, A., & Abbaszadegan, M. R. (2021). Non-collagenous extracellular matrix protein dermatopontin may play a role as another component of transforming growth factor-β signaling pathway in colon carcinogenesis. Iranian Journal of Basic Medical Sciences, 24(4), 444.

Liu, S., Qiu, J., He, G., Geng, C., He, W., Liu, C., ... & Tian, Q. (2020). Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma. Journal of Cancer, 11(21), 6288.

Unamuno, X., Gómez-Ambrosi, J., Ramírez, B., Rodríguez, A., Becerril, S., Valentí, V., ... & Catalán, V. (2020). Dermatopontin, a novel adipokine promoting adipose tissue extracellular matrix remodelling and inflammation in obesity. Journal of clinical medicine, 9(4), 1069.

Seetaraman Amritha, T. M., Mahajan, S., Subramaniam, K., Chandramohan, Y., & Dhanasekaran, A. (2020). Cloning, expression and purification of recombinant dermatopontin in Escherichia coli. Plos one, 15(11), e0242798.

Kim, T., Ahmad, K., Shaikh, S., Jan, A. T., Seo, M. G., Lee, E. J., & Choi, I. (2019). Dermatopontin in skeletal muscle extracellular matrix regulates myogenesis. Cells, 8(4), 332.

Guo, Y., Li, H., Guan, H., Ke, W., Liang, W., Xiao, H., & Li, Y. (2019). Dermatopontin inhibits papillary thyroid cancer cell proliferation through MYC repression. Molecular and cellular endocrinology, 480, 122-132.

Krishnaswamy, V. R., Balaguru, U. M., Chatterjee, S., & Korrapati, P. S. (2017). Dermatopontin augments angiogenesis and modulates the expression of transforming growth factor beta 1 and integrin alpha 3 beta 1 in endothelial cells. European Journal of Cell Biology, 96(3), 266-275.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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