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Mouse Anti-DPT Recombinant Antibody (2A11) (V2LY-0425-LY883)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2A11
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
DPT (aa101-201) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dermatopontin
Entrez Gene ID
1805
UniProt ID
Q07507
Function
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
Biological Process
Cell adhesion Source: UniProtKB-KW
Collagen fibril organization Source: GO_Central
Negative regulation of cell population proliferation Source: Ensembl
Cellular Location
Extracellular matrix
PTM
Sulfated on tyrosine residue(s).
More Infomation

Jensen, M. M., Bonna, A., Frederiksen, S. J., Hamaia, S. W., Højrup, P., Farndale, R. W., & Karring, H. (2022). Tyrosine-sulfated dermatopontin shares multiple binding sites and recognition determinants on triple-helical collagens with proteins implicated in cell adhesion and collagen folding, fibrillogenesis, cross-linking, and degradation. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1870(5), 140771.

Huang, H., Hao, Z., Long, L., Yin, Z., Wu, C., Zhou, X., & Zhang, B. (2021). Dermatopontin as a potential pathogenic factor in endometrial cancer. Oncology Letters, 21(5), 1-8.

Kramer, A. C., Astuti, Y., Elfstrum, A., Lehrke, M. J., Tolar, J., Blazar, B. R., ... & Lund, T. C. (2021). An irradiated marrow niche reveals a small noncollagenous protein mediator of homing, dermatopontin. Blood Advances, 5(18), 3609-3622.

Sadr-Nabavi, A., Bouromand-Noughabi, S., Tayebi-Meybodi, N., Dadkhah, K., Amini, N., Meindl, A., & Abbaszadegan, M. R. (2021). Non-collagenous extracellular matrix protein dermatopontin may play a role as another component of transforming growth factor-β signaling pathway in colon carcinogenesis. Iranian Journal of Basic Medical Sciences, 24(4), 444.

Liu, S., Qiu, J., He, G., Geng, C., He, W., Liu, C., ... & Tian, Q. (2020). Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma. Journal of Cancer, 11(21), 6288.

Unamuno, X., Gómez-Ambrosi, J., Ramírez, B., Rodríguez, A., Becerril, S., Valentí, V., ... & Catalán, V. (2020). Dermatopontin, a novel adipokine promoting adipose tissue extracellular matrix remodelling and inflammation in obesity. Journal of clinical medicine, 9(4), 1069.

Seetaraman Amritha, T. M., Mahajan, S., Subramaniam, K., Chandramohan, Y., & Dhanasekaran, A. (2020). Cloning, expression and purification of recombinant dermatopontin in Escherichia coli. Plos one, 15(11), e0242798.

Kim, T., Ahmad, K., Shaikh, S., Jan, A. T., Seo, M. G., Lee, E. J., & Choi, I. (2019). Dermatopontin in skeletal muscle extracellular matrix regulates myogenesis. Cells, 8(4), 332.

Guo, Y., Li, H., Guan, H., Ke, W., Liang, W., Xiao, H., & Li, Y. (2019). Dermatopontin inhibits papillary thyroid cancer cell proliferation through MYC repression. Molecular and cellular endocrinology, 480, 122-132.

Krishnaswamy, V. R., Balaguru, U. M., Chatterjee, S., & Korrapati, P. S. (2017). Dermatopontin augments angiogenesis and modulates the expression of transforming growth factor beta 1 and integrin alpha 3 beta 1 in endothelial cells. European Journal of Cell Biology, 96(3), 266-275.

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For research use only. Not intended for any clinical use.

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