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Mouse Anti-DPY30 Recombinant Antibody (CBYCD-396) (V2LY-0425-LY885)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYCD-396
Antibody Isotype
IgG1
Application
IF, WB

Basic Information

Immunogen
Recombinant protein within mouse dpy30 (aa 1-99).
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol & PBS
Preservative
Sodium Azide
Concentration
2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dpy-30, Histone Methyltransferase Complex Regulatory Subunit
Entrez Gene ID
84661
UniProt ID
Q9C005
Function
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.
Biological Process
Chromatin silencing at telomere Source: GO_Central
Endosomal transport Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
Cellular Location
Trans-Golgi network; Nucleus. Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity).
More Infomation

Dixit, D., Prager, B. C., Gimple, R. C., Miller, T. E., Wu, Q., Yomtoubian, S., ... & Rich, J. N. (2022). Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases. Science translational medicine, 14(626), eabf3917.

Zhao, Y., Hao, X., Li, Z., Feng, X., Katz, J., Michalek, S. M., ... & Zhang, P. (2022). Role of chromatin modulator Dpy30 in osteoclast differentiation and function. Bone, 159, 116379.

Shah, K. K., Whitaker, R. H., Busby, T., Hu, J., Shi, B., Wang, Z., ... & Jiang, H. (2019). Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth. Experimental cell research, 382(2), 111485.

Liu, B. (2018). DPY30 functions in glucose homeostasis via integrating activated histone epigenetic modifications. Biochemical and biophysical research communications, 507(1-4), 286-290.

Zhang, L., Zhang, S., Li, A., Zhang, A., Zhang, S., & Chen, L. (2018). DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells. International journal of molecular medicine, 42(6), 3065-3072.

Bieluszewska, A., Weglewska, M., Bieluszewski, T., Lesniewicz, K., & Poreba, E. (2018). PKA‐binding domain of AKAP 8 is essential for direct interaction with DPY 30 protein. The FEBS journal, 285(5), 947-964.

Haddad, J. F., Yang, Y., Takahashi, Y. H., Joshi, M., Chaudhary, N., Woodfin, A. R., ... & Couture, J. F. (2018). Structural analysis of the Ash2L/Dpy-30 complex reveals a heterogeneity in H3K4 methylation. Structure, 26(12), 1594-1603.

Ali, A., & Tyagi, S. (2017). Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family. Journal of biosciences, 42(1), 155-159.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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