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Mouse Anti-DPY30 Recombinant Antibody (EG994) (CBMAB-EN1177-LY)

The product is antibody recognizes DPY30. The antibody EG994 immunoassay techniques such as: ELISA, WB.
See all DPY30 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
EG994
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length of Human DPY30
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dpy-30, Histone Methyltransferase Complex Regulatory Subunit
Introduction
This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]
Entrez Gene ID
84661
UniProt ID
Q9C005
Alternative Names
Dpy-30, Histone Methyltransferase Complex Regulatory Subunit; Dpy-30-Like Protein; Dpy-30L; Dpy-30 Homolog (C. Elegans); Protein Dpy-30 Homolog; Dpy-30 Homolog; HDPY-30; Cps25; Saf19;
Function
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.
Biological Process
Chromatin silencing at telomere Source: GO_Central
Endosomal transport Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
Cellular Location
Trans-Golgi network; Nucleus. Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys-4. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs (By similarity).

Dixit, D., Prager, B. C., Gimple, R. C., Miller, T. E., Wu, Q., Yomtoubian, S., ... & Rich, J. N. (2022). Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases. Science translational medicine, 14(626), eabf3917.

Zhao, Y., Hao, X., Li, Z., Feng, X., Katz, J., Michalek, S. M., ... & Zhang, P. (2022). Role of chromatin modulator Dpy30 in osteoclast differentiation and function. Bone, 159, 116379.

Shah, K. K., Whitaker, R. H., Busby, T., Hu, J., Shi, B., Wang, Z., ... & Jiang, H. (2019). Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth. Experimental cell research, 382(2), 111485.

Liu, B. (2018). DPY30 functions in glucose homeostasis via integrating activated histone epigenetic modifications. Biochemical and biophysical research communications, 507(1-4), 286-290.

Zhang, L., Zhang, S., Li, A., Zhang, A., Zhang, S., & Chen, L. (2018). DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells. International journal of molecular medicine, 42(6), 3065-3072.

Bieluszewska, A., Weglewska, M., Bieluszewski, T., Lesniewicz, K., & Poreba, E. (2018). PKA‐binding domain of AKAP 8 is essential for direct interaction with DPY 30 protein. The FEBS journal, 285(5), 947-964.

Haddad, J. F., Yang, Y., Takahashi, Y. H., Joshi, M., Chaudhary, N., Woodfin, A. R., ... & Couture, J. F. (2018). Structural analysis of the Ash2L/Dpy-30 complex reveals a heterogeneity in H3K4 methylation. Structure, 26(12), 1594-1603.

Ali, A., & Tyagi, S. (2017). Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family. Journal of biosciences, 42(1), 155-159.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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